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Glycoprotein Hormone Alpha-subunit in Pituitary Adenomas

Overview
Specialty Endocrinology
Date 1992 Mar 1
PMID 18407076
Citations 20
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Abstract

Elevated serum glycoprotein hormone alpha-subunit (alpha-subunit) levels are seen in about one of six patients bearing pituitary adenomas. This finding has particular clinical significance in patients with nonfunctioning pituitary adenomas. Moreover, the measurement of alpha-subunit along with the calculation of the molar ratio between alpha-subunit and TSH, LH, or FSH is helpful in the diagnosis of glycoprotein hormone-secreting pituitary adenomas. Since serum alpha-subunit levels may vary greatly in several physiologic and pathologic conditions, care has to be taken to differentiate abnormal from normal states of alpha-subunit hypersecretion as well as to exclude causes of alpha-subunit overproduction only casually associated with the presence of pituitary tumors.

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