Potential Functions of Plasma Steroid-binding Proteins

The plasma steroid-binding proteins, sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), transport steroid hormones in the blood and regulate their access to target tissues. Recent biochemical and molecular analyses of these proteins and their genes, and studies of their biosynthesis and localization in the liver and other tissues during development, have led to the realization that CBG and SHBG function in much more sophisticated ways. In particular, the presence of plasma membrane binding sites for both CBG and SHBG on steroid target cells, and evidence for interactions between CBG and specific proteinases at sites of inflammation or tissue remodeling, suggest that these proteins control steroid hormone bioavailability and/or action in a highly selective or targeted fashion. This new information should not only serve to extend our understanding of the basis of steroid-hormone dependent diseases, but may influence the design of steroid hormone agonists and antagonist of therapeutic potential.