P2X(7) Receptor: Death or Life?

Overview

Journal Purinergic Signal

Publisher Springer

Date 2008 Apr 12

PMID 18404507

Citations 66

Authors

Elena Adinolfi

Cinzia Pizzirani

Marco Idzko

Elisabeth Panther

Johannes Norgauer

Francesco Di Virgilio

Davide Ferrari

Affiliations

Soon will be listed here.

Abstract

The P2X(7) plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of P2X(7)-mediated responses, discussing recent information on this receptor. Particular attention has been paid to early and late signs of apoptosis and necrosis linked to activation of the receptor and to the emerging field of P2X(7) function in carcinogenesis.

Citing Articles

Increased Pan-Type, A1-Type, and A2-Type Astrocyte Activation and Upstream Inflammatory Markers Are Induced by the P2X7 Receptor.

Campagno K, Sripinun P, See L, Li J, Lu W, Jassim A Int J Mol Sci. 2024; 25(16).

PMID: 39201471 PMC: 11354399. DOI: 10.3390/ijms25168784.

Extracellular ATP/P2X7 receptor, a regulatory axis of migration in ovarian carcinoma-derived cells.

Nunez-Rios J, Reyna-Jeldes M, Mata-Martinez E, Campos-Contreras A, Lazcano-Sanchez I, Gonzalez-Gallardo A PLoS One. 2024; 19(6):e0304062.

PMID: 38870128 PMC: 11175443. DOI: 10.1371/journal.pone.0304062.

Exploring the Three-Dimensional Frontier: Advancements in MSC Spheroids and Their Implications for Breast Cancer and Personalized Regenerative Therapies.

Smolinska V, Harsanyi S, Bohac M, Danisovic L Biomedicines. 2024; 12(1).

PMID: 38255159 PMC: 10813175. DOI: 10.3390/biomedicines12010052.

The P2X7 Receptor in Oncogenesis and Metastatic Dissemination: New Insights on Vesicular Release and Adenosinergic Crosstalk.

Adinolfi E, De Marchi E, Grignolo M, Szymczak B, Pegoraro A Int J Mol Sci. 2023; 24(18).

PMID: 37762206 PMC: 10531279. DOI: 10.3390/ijms241813906.

Purinergic signaling: Diverse effects and therapeutic potential in cancer.

Kaur J, Dora S Front Oncol. 2023; 13:1058371.

PMID: 36741002 PMC: 9889871. DOI: 10.3389/fonc.2023.1058371.

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