Nucleotide Receptor Signalling and the Generation of Reactive Oxygen Species

Overview

Journal Purinergic Signal

Publisher Springer

Date 2008 Apr 12

PMID 18404417

Citations 26

Authors

Alma N Guerra

Monica L Gavala

Hun Sun Chung

Paul J Bertics

Affiliations

Soon will be listed here.

Abstract

Elevated levels of extracellular nucleotides are present at sites of inflammation, platelet degranulation and cellular damage or lysis. These extracellular nucleotides can lead to the activation of purinergic (nucleotide) receptors on various leukocytes, including monocytes, macrophages, eosinophils, and neutrophils. In turn, nucleotide receptor activation has been linked to increased cellular production and release of multiple inflammatory mediators, including superoxide anion, nitric oxide and other reactive oxygen species (ROS). In the present review, we will summarize the evidence that extracellular nucleotides can facilitate the generation of multiple ROS by leukocytes. In addition, we will discuss several potential mechanisms by which nucleotide-enhanced ROS production may occur. Delineation of these mechanisms is important for understanding the processes associated with nucleotide-induced antimicrobial activities, cell signalling, apoptosis, and pathology.

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