P1 Receptors and Cytokine Secretion

Overview

Journal Purinergic Signal

Publisher Springer

Date 2008 Apr 12

PMID 18404415

Citations 20

Authors

Maria P Abbracchio

Stefania Ceruti

Affiliations

Soon will be listed here.

Abstract

Evidence has accumulated in the last three decades to suggest tissue protection and regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or inflamed environments reduces tissue injury and promotes repair by receptor-mediated mechanisms. Among other actions, regulation of cytokine production and secretion by immune cells, astrocytes and microglia (the brain immunocytes) has emerged as a main mechanism at the basis of adenosine effects in diseases characterized by a marked inflammatory component. Many recent studies have highlighted that signalling through A(1) and A(2A) adenosine receptors can powerfully prevent the release of pro-inflammatory cytokines, thus inhibiting inflammation and reperfusion injury. However, the activation of adenosine receptors is not invariably protective of tissues, as signalling through the A(2B) adenosine receptor has been linked to pro-inflammatory actions which are, at least in part, mediated by increased release of pro-inflammatory cytokines from epithelial cells, astrocytes and fibroblasts. Here, we discuss the multiple actions of P1 receptors on cytokine secretion, by analyzing, in particular, the role of the various adenosine receptor subtypes, the complex reciprocal interplay between the adenosine and the cytokine systems, their pathophysiological significance and the potential of adenosine receptor ligands as new anti-inflammatory agents.

Citing Articles

Adenosine in Interventional Cardiology: Physiopathologic and Pharmacologic Effects in Coronary Artery Disease.

Marchi E, Muraca I, Berteotti M, Gori A, Valenti R, Marcucci R Int J Mol Sci. 2024; 25(11).

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Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation.

Kiaie S, Hatami Z, Nasr M, Pazooki P, Hemmati S, Baradaran B Purinergic Signal. 2023; 20(4):321-343.

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Effect of adenosine treatment on ionizing radiation toxicity in zebrafish early life stages.

Cruz F, Pereira T, da Costa K, Bonan C, Bogo M, Morrone F Naunyn Schmiedebergs Arch Pharmacol. 2023; 397(1):521-534.

PMID: 37480487 DOI: 10.1007/s00210-023-02617-z.

Roles of Adenosine Receptor (subtypes A and A) in Cuprizone-Induced Hippocampal Demyelination.

Adebiyi O, Bynoe M Mol Neurobiol. 2023; 60(10):5878-5890.

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Adenosine A2B Receptors - Mediated Induction of Interleukin-6 in Skeletal Muscle Cells.

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