A New Prenylated Dihydrochalcone from the Leaves of Artocarpus Lowii

Overview

Journal J Nat Med

Publisher Springer

Date 2008 Apr 12

PMID 18404311

Citations 8

Authors

Shajarahtunnur Jamil

Hasnah Mohd Sirat

Ibrahim Jantan

Norio Aimi

Mariko Kitajima

Affiliations

Soon will be listed here.

Abstract

A new prenylated dihydrochalcone, 2',4'-dihydroxy-4-methoxy-3'-prenyldihydrochalcone (1), along with two known compounds, 2',4',4-trihydroxy-3'-prenylchalcone (2) and 2',4-dihydroxy-3',4'-(2,2-dimethylchromene)chalcone (3) were isolated from the leaves of Artocarpus lowii. The structures of 1-3 were elucidated by spectroscopic methods and by comparison with data reported in the literature. Compounds 1-3 showed strong free radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl (DPPH) measured by electron spin resonance (ESR) spectrometry.

Citing Articles

Untargeted Metabolomics Profiling of Arabidopsis WT, and Mutants Following Treatment with Two LPS Chemotypes.

Offor B, Mhlongo M, Steenkamp P, Dubery I, Piater L Metabolites. 2022; 12(5).

PMID: 35629883 PMC: 9146344. DOI: 10.3390/metabo12050379.

Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis.

Cheng M, Ding L, Kan H, Zhang H, Jiang B, Sun Y J Nat Med. 2019; 73(4):847-854.

PMID: 31218551 DOI: 10.1007/s11418-019-01329-0.

Anti-Inflammatory Pyranochalcone Derivative Attenuates LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Pathway.

Shi M, Zeng X, Guo F, Huang R, Feng Y, Ma L Molecules. 2017; 22(10).

PMID: 28994737 PMC: 6151422. DOI: 10.3390/molecules22101683.

Chemistry and pharmacology of 4-hydroxylonchocarpin: a review.

Kuete V, Noumedem J, Nana F Chin J Integr Med. 2013; 19(6):475-80.

PMID: 23784469 DOI: 10.1007/s11655-013-1195-7.

Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett.

Hashim N, Rahmani M, Ee G, Sukari M, Yahayu M, Amin M Molecules. 2012; 17(5):6071-82.

PMID: 22614861 PMC: 6268949. DOI: 10.3390/molecules17056071.

References

Wei B, Weng J, Chiu P, Hung C, Wang J, Lin C . Antiinflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis. J Agric Food Chem. 2005; 53(10):3867-71. DOI: 10.1021/jf047873n. View

Abegaz B, Ngadjui B, Dongo E, Ngameni B, Nindi M, Bezabih M . Chalcones and other constituents of Dorstenia prorepens and Dorstenia zenkeri. Phytochemistry. 2002; 59(8):877-83. DOI: 10.1016/s0031-9422(01)00483-6. View

Wang Y, Hou A, Chen L, Chen D, Sun H, Zhao Q . New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama. J Nat Prod. 2004; 67(5):757-61. DOI: 10.1021/np030467y. View

Ko F, Cheng Z, Lin C, Teng C . Scavenger and antioxidant properties of prenylflavones isolated from Artocarpus heterophyllus. Free Radic Biol Med. 1998; 25(2):160-8. DOI: 10.1016/s0891-5849(98)00031-8. View

Ko H, Lu Y, Yang S, Won S, Lin C . Cytotoxic prenylflavonoids from Artocarpus elasticus. J Nat Prod. 2005; 68(11):1692-5. DOI: 10.1021/np050287j. View