Characteristics of Well-differentiated Thyroid Cancer Associated with Multinodular Goiter

Overview

Journal Langenbecks Arch Surg

Specialty General Surgery

Date 2008 Apr 12

PMID 18404277

Citations 3

Authors

Shih-Ping Cheng

Chien-Liang Liu

Chi-Yuan Tzen

Tsen-Long Yang

Kuo-Shyang Jeng

Tsang-Pai Liu

Jie-Jen Lee

Affiliations

Soon will be listed here.

Abstract

Background: The likelihood of thyroid cancer is similar in patients with one or more nodules, but tumor characteristics of thyroid cancer in glands with multinodular goiter are unclear.

Materials And Methods: This study consisted of 100 consecutive patients (ages 15-81 years; 84 women), who underwent thyroidectomy for papillary or follicular thyroid carcinoma between 2005 and 2006. Patient demographics, diagnostic tests, operations, and pathological findings were reviewed.

Results: In a univariate analysis, cancer diagnosed within multinodular goiter was different from solitary cancer nodule in age of diagnosis (48 vs 40 years, p = 0.002), tumor size (1.42 vs 2.20 cm, p = 0.024), and the presence of cervical lymph node metastases (p = 0.035). There was no difference in gender, extrathyroidal invasion, multifocality, and types of operation. Only age (odds ratio, 1.056) and tumor size (odds ratio, 0.730) revealed independent correlation in multivariate analysis.

Conclusion: Thyroid cancer in glands with multiple nodules is associated with older age at diagnosis and smaller tumor size.

Citing Articles

Solitary and multiple thyroid nodules as predictors of malignancy: a systematic review and meta-analysis.

Rehman A, Ehsan M, Javed H, Ameer M, Mohsin A, Rehman M Thyroid Res. 2022; 15(1):22.

PMID: 36464691 PMC: 9720983. DOI: 10.1186/s13044-022-00140-6.

Preoperative Factors Associated with Extrathyroidal Extension in Papillary Thyroid Cancer.

Kuo C, Yang P, Chien M, Cheng S Eur Thyroid J. 2020; 9(5):256-262.

PMID: 33088794 PMC: 7548880. DOI: 10.1159/000506474.

Genetic Alterations in Hungarian Patients with Papillary Thyroid Cancer.

Tobias B, Halaszlaki C, Balla B, Kosa J, Arvai K, Horvath P Pathol Oncol Res. 2015; 22(1):27-33.

PMID: 26259532 DOI: 10.1007/s12253-015-9969-9.

References

Tollin S, Mery G, Jelveh N, Fallon E, Mikhail M, BLUMENFELD W . The use of fine-needle aspiration biopsy under ultrasound guidance to assess the risk of malignancy in patients with a multinodular goiter. Thyroid. 2000; 10(3):235-41. DOI: 10.1089/thy.2000.10.235. View

Kapur M, Sarda A, Bal S, Sood S . Carcinoma of the thyroid: differential behaviour in solitary and multinodular tumours. Br J Surg. 1986; 73(11):894-5. DOI: 10.1002/bjs.1800731113. View

Knudsen N, Laurberg P, Perrild H, Bulow I, Ovesen L, Jorgensen T . Risk factors for goiter and thyroid nodules. Thyroid. 2002; 12(10):879-88. DOI: 10.1089/105072502761016502. View

Giles Y, Boztepe H, Terzioglu T, Tezelman S . The advantage of total thyroidectomy to avoid reoperation for incidental thyroid cancer in multinodular goiter. Arch Surg. 2004; 139(2):179-82. DOI: 10.1001/archsurg.139.2.179. View

Frates M, Benson C, Doubilet P, Kunreuther E, Contreras M, Cibas E . Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab. 2006; 91(9):3411-7. DOI: 10.1210/jc.2006-0690. View

Rios A, Rodriguez J, Galindo P, Montoya M, Tebar F, Sola J . Utility of fine-needle aspiration for diagnosis of carcinoma associated with multinodular goitre. Clin Endocrinol (Oxf). 2004; 61(6):732-7. DOI: 10.1111/j.1365-2265.2004.02157.x. View

Cooper D, Doherty G, Haugen B, Kloos R, Lee S, Mandel S . Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2006; 16(2):109-42. DOI: 10.1089/thy.2006.16.109. View

Diez J . Goiter in adult patients aged 55 years and older: etiology and clinical features in 634 patients. J Gerontol A Biol Sci Med Sci. 2005; 60(7):920-3. DOI: 10.1093/gerona/60.7.920. View

Papini E, Guglielmi R, Bianchini A, Crescenzi A, Taccogna S, Nardi F . Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab. 2002; 87(5):1941-6. DOI: 10.1210/jcem.87.5.8504. View

10.

Frates M, Benson C, Charboneau J, Cibas E, Clark O, Coleman B . Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology. 2005; 237(3):794-800. DOI: 10.1148/radiol.2373050220. View

11.

Lang B, Lo C, Chan W, Lam K, Wan K . Staging systems for papillary thyroid carcinoma: a review and comparison. Ann Surg. 2007; 245(3):366-78. PMC: 1877011. DOI: 10.1097/01.sla.0000250445.92336.2a. View

12.

Cerci C, Cerci S, Eroglu E, Dede M, Kapucuoglu N, Yildiz M . Thyroid cancer in toxic and non-toxic multinodular goiter. J Postgrad Med. 2007; 53(3):157-60. DOI: 10.4103/0022-3859.33855. View

13.

Erbil Y, Barbaros U, Salmaslioglu A, Yanik B, Bozbora A, Ozarmagan S . The advantage of near-total thyroidectomy to avoid postoperative hypoparathyroidism in benign multinodular goiter. Langenbecks Arch Surg. 2006; 391(6):567-73. DOI: 10.1007/s00423-006-0091-z. View

14.

Gharib H, Papini E . Thyroid nodules: clinical importance, assessment, and treatment. Endocrinol Metab Clin North Am. 2007; 36(3):707-35, vi. DOI: 10.1016/j.ecl.2007.04.009. View

15.

Rios A, Rodriguez J, Canteras M, Galindo P, Balsalobre M, Parrilla P . Risk factors for malignancy in multinodular goitres. Eur J Surg Oncol. 2004; 30(1):58-62. DOI: 10.1016/j.ejso.2003.10.021. View

16.

Wadstrom C, Zedenius J, Guinea A, Reeve T, Delbridge L . Multinodular goitre presenting as a clinical single nodule: how effective is hemithyroidectomy?. Aust N Z J Surg. 1999; 69(1):34-6. DOI: 10.1046/j.1440-1622.1999.01485.x. View

17.

Hegedus L . Clinical practice. The thyroid nodule. N Engl J Med. 2004; 351(17):1764-71. DOI: 10.1056/NEJMcp031436. View

18.

Bakiri F, Hassaim M, Bourouba M . Subtotal thyroidectomy for benign multinodular goiter: a 6-month postoperative study of the remnant's function and sonographic aspect. World J Surg. 2006; 30(6):1096-9. DOI: 10.1007/s00268-005-0570-3. View

19.

Derwahl M, STUDER H . Multinodular goitre: 'much more to it than simply iodine deficiency'. Baillieres Best Pract Res Clin Endocrinol Metab. 2001; 14(4):577-600. DOI: 10.1053/beem.2000.0104. View

20.

Tan G, Gharib H . Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging. Ann Intern Med. 1997; 126(3):226-31. DOI: 10.7326/0003-4819-126-3-199702010-00009. View