Age and Motor Score Predict Osteoprotegerin Level in Chronic Spinal Cord Injury

Overview

Journal J Musculoskelet Neuronal Interact

Specialties Neurology
Orthopedics
Physiology

Date 2008 Apr 10

PMID 18398265

Citations 6

Authors

L R Morse

H P Nguyen

N Jain

S Williams

C G Tun

R A Battaglino

P Stashenko

E Garshick

Affiliations

Soon will be listed here.

Abstract

Objective: Individuals with spinal cord injury (SCI) develop a severe form of osteoporosis below the level of injury that is poorly understood. We conducted a preliminary investigation to assess whether circulating markers of bone turnover and circulating RANKL/OPG levels are related to the severity of SCI, aging, or to differences in mobility (i.e., walking or using a wheelchair).

Methods: Sixty-four caucasian men >or=1.6 years since injury selected based on locomotive mode provided blood samples and completed a health questionnaire at the VA Boston Healthcare System from 10/2003 to 6/2005. Plasma sRANKL, osteoprotegerin (OPG), osteocalcin and carboxyterminal telopeptide of type I collagen (CTx) levels were determined.

Results: Increasing age was significantly associated with increased OPG and CTx. Injury severity was predictive of OPG levels, and adjusting for age, participants with cervical motor complete and ASIA C SCI (n=11) had significantly lower mean OPG (46.1 pg/ml) levels than others (63.4 pg/ml). Locomotive mode was not associated with differences in bone markers.

Conclusions: Severe cervical spinal cord injury is associated with decreased circulating OPG levels placing these patients at risk for accelerated bone loss that appears unrelated to locomotive mode.

Citing Articles

The Pathophysiology, Identification and Management of Fracture Risk, Sublesional Osteoporosis and Fracture among Adults with Spinal Cord Injury.

Craven B, Cirnigliaro C, Carbone L, Tsang P, Morse L J Pers Med. 2023; 13(6).

PMID: 37373955 PMC: 10300795. DOI: 10.3390/jpm13060966.

Prevention and management of osteoporosis and osteoporotic fractures in persons with a spinal cord injury or disorder: A systematic scoping review.

Zleik N, Weaver F, Harmon R, Le B, Radhakrishnan R, Jirau-Rosaly W J Spinal Cord Med. 2018; 42(6):735-759.

PMID: 29745791 PMC: 6830234. DOI: 10.1080/10790268.2018.1469808.

Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy.

Gifre L, Ruiz-Gaspa S, Carrasco J, Portell E, Vidal J, Muxi A Osteoporos Int. 2017; 28(9):2707-2715.

PMID: 28580511 DOI: 10.1007/s00198-017-4090-4.

The Relationship Between Dietary Intakes of Amino Acids and Bone Mineral Density Among Individuals with Spinal Cord Injury.

Sabour H, Nazari M, Latifi S, Soltani Z, Shakeri H, Larijani B Oman Med J. 2016; 31(1):22-8.

PMID: 26816565 PMC: 4720942. DOI: 10.5001/omj.2016.05.

VA-based survey of osteoporosis management in spinal cord injury.

Morse L, Giangregorio L, Battaglino R, Holland R, Craven B, Stolzmann K PM R. 2009; 1(3):240-4.

PMID: 19627901 PMC: 2791704. DOI: 10.1016/j.pmrj.2008.10.008.

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