Human Regulatory T Cells and Autoimmunity

Overview

Journal Eur J Immunol

Specialty Allergy & Immunology

Date 2008 Apr 9

PMID 18395861

Citations 62

Authors

Cristina M Costantino

Clare M Baecher-Allan

David A Hafler

Affiliations

Soon will be listed here.

Abstract

CD4+CD25+ regulatory T cells (Treg) appear to be critical in regulating immune responses to self-antigens. Treg deficiency is associated with several human autoimmune diseases. Although substantial progress has been made in the study of murine and human Treg, their fundamental mechanism of action remains unknown. In this review, we discuss the phenotype of human natural Treg, their functional mechanism, and their role in autoimmune disease.

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