The Genetics of Essential Metal Homeostasis During Development

Overview

Journal Genesis

Specialties Biology
Molecular Biology

Date 2008 Apr 9

PMID 18395838

Citations 45

Authors

Taiho Kambe

Benjamin P Weaver

Glen K Andrews

Affiliations

Soon will be listed here.

Abstract

The essential metals copper, zinc, and iron play key roles in embryonic, fetal, and postnatal development in higher eukaryotes. Recent advances in our understanding of the molecules involved in the intricate control of the homeostasis of these metals and the availability of natural mutations and targeted mutations in many of the genes involved have allowed for elucidation of the diverse roles of these metals during development. Evidence suggests that the ability of the embryo to control the homeostasis of these metals becomes essential at the blastocyst stage and during early morphogenesis. However, these metals play unique roles throughout development and exert pleiotropic, metal-specific, and often cell-specific effects on morphogenesis, growth, and differentiation. Herein, we briefly review the major players known to be involved in the homeostasis of each of these essential metals and their known roles in development.

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