Recent Developments in Urologic Oncology: Positron Emission Tomography Molecular Imaging

Overview

Journal Curr Opin Oncol

Specialty Oncology

Date 2008 Apr 9

PMID 18391633

Citations 11

Authors

Kirsten Bouchelouche

Peter Oehr

Affiliations

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Abstract

Purpose Of Review: Traditional morphologically based imaging modalities in uro-oncology are now being complemented by the functional and molecular imaging technique positron emission tomography (PET). This review highlights the most important recent developments.

Recent Findings: Prostate cancer: PET imaging with the new radiotracers 11C-choline, 18F-fluorocholine, and 11C-acetate show promising results. The role of anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid remains to be elucidated further. 18F-fluoride PET is useful for the detection of bone metastases. Bladder cancer: 18F-fluorodeoxyglucose (FDG) PET/CT with delayed images after a diuretic and oral hydration may improve detection of locally recurrent or residual bladder tumours. Both 18F-FDG PET and 11C-choline PET may be useful for staging of bladder cancer. Renal cancer: 18F-FDG PET has a role in staging and restaging of the disease. Recently, 124I-cG250 PET has shown promising results in the detection of clear-cell renal carcinoma. Testicular cancer: 18F-FDG PET is useful in staging and follow-up after treatment. There are no important recent developments with new radiopharmaceuticals in testicular cancer.

Summary: The utility of PET molecular imaging in uro-oncology expanded due to the new metabolic PET tracers with more favourable properties.

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Evaluation of Dose-Painting in the Dominant Intraprostatic Lesions by Radiobiological Parameters using Ga- PSMA PET/CT.

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Bresler R, Schroeder H, Chow D, Lim R World J Nucl Med. 2020; 19(2):124-130.

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PET/CT Imaging in Oncology: Exceptions That Prove the Rule.

Casali M, Froio A, Carbonelli C, Versari A Case Rep Oncol Med. 2013; 2013:865032.

PMID: 23533875 PMC: 3600207. DOI: 10.1155/2013/865032.