» Articles » PMID: 18388211

MR Imaging-based Decision in Thrombolytic Therapy for Stroke on Awakening: Report of 2 Cases

Overview
Specialty Neurology
Date 2008 Apr 5
PMID 18388211
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

Patients with stroke on awakening are denied the potential benefit of thrombolysis on the grounds that the onset time is unknown. Relying on clinical and MR imaging to indicate the most appropriate treatment could be more rational. We report 2 cases of stroke with unknown onset time. In both cases, anamnesis and MR imaging indicated that we might still be within 6 hours from stroke onset, with salvageable tissue. Arterial recanalization was successfully performed in both cases.

Citing Articles

Wake-up stroke: imaging-based diagnosis and recanalization therapy.

Zhang Y, Zhang J, Wang X, Wang Y, Anderson C, Wu Y J Neurol. 2020; 268(11):4002-4012.

PMID: 32671526 DOI: 10.1007/s00415-020-10055-7.


Wake-up stroke and CT perfusion: effectiveness and safety of reperfusion therapy.

Caruso P, Naccarato M, Furlanis G, Ajcevic M, Stragapede L, Ridolfi M Neurol Sci. 2018; 39(10):1705-1712.

PMID: 29987433 DOI: 10.1007/s10072-018-3486-z.


Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results.

Schwamm L, Wu O, Song S, Latour L, Ford A, Hsia A Ann Neurol. 2018; 83(5):980-993.

PMID: 29689135 PMC: 6095471. DOI: 10.1002/ana.25235.


What to do With Wake-Up Stroke.

Rubin M, Barrett K Neurohospitalist. 2015; 5(3):161-72.

PMID: 26288674 PMC: 4530419. DOI: 10.1177/1941874415576204.


Wake-up stroke and stroke of unknown onset: a critical review.

Wouters A, Lemmens R, Dupont P, Thijs V Front Neurol. 2014; 5:153.

PMID: 25161646 PMC: 4129498. DOI: 10.3389/fneur.2014.00153.


References
1.
Hellier K, Hampton J, Guadagno J, Higgins N, Antoun N, Day D . Perfusion CT helps decision making for thrombolysis when there is no clear time of onset. J Neurol Neurosurg Psychiatry. 2006; 77(3):417-9. PMC: 2077703. DOI: 10.1136/jnnp.2005.067363. View

2.
Serena J, Davalos A, Segura T, Mostacero E, Castillo J . Stroke on awakening: looking for a more rational management. Cerebrovasc Dis. 2003; 16(2):128-33. DOI: 10.1159/000070592. View

3.
Schellinger P, Fiebach J, Hacke W . Imaging-based decision making in thrombolytic therapy for ischemic stroke: present status. Stroke. 2003; 34(2):575-83. View

4.
Lansberg M, Thijs V, OBrien M, Ali J, de Crespigny A, Tong D . Evolution of apparent diffusion coefficient, diffusion-weighted, and T2-weighted signal intensity of acute stroke. AJNR Am J Neuroradiol. 2001; 22(4):637-44. PMC: 7976036. View

5.
Sylaja P, Dzialowski I, Krol A, Roy J, Federico P, Demchuk A . Role of CT angiography in thrombolysis decision-making for patients with presumed seizure at stroke onset. Stroke. 2006; 37(3):915-7. DOI: 10.1161/01.STR.0000202678.86234.84. View