Dihydroartemisinin-piperaquine Rescue Treatment of Multidrug-resistant Plasmodium Falciparum Malaria in Pregnancy: a Preliminary Report

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2008 Apr 4

PMID 18385345

Citations 28

Authors

Marcus J Rijken

Rose McGready

Machteld E Boel

Marion Barends

Stephane Proux

Mupawjay Pimanpanarak

Pratap Singhasivanon

Francois Nosten

Affiliations

Soon will be listed here.

Abstract

Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).

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