Antithymocyte Globulin and Cyclosporin in Children with Acquired Aplastic Anemia

Overview

Journal Indian J Pediatr

Specialty Pediatrics

Date 2008 Apr 1

PMID 18376089

Citations 7

Authors

Jagdish Chandra

Rahul Naithani

Rakesh Ravi

Varinder Singh

Shashi Narayan

Sunita Sharma

Harish Pemde

A K Dutta

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the responses to ATG and cyclosporin combination in patients of aplastic anemia.

Methods: Twenty three (17M: 6F) patients of aplastic anemia (11 very severe aplastic anemia (VSAA) and 12 severe aplastic anemia (SAA), were administered antithymocyte globulin and cyclosporin.

Results: The median age of patents was 8 years (range 6-12 years). Three patients died within 2 months of therapy. Twenty children (11 SAA and 9 VSAA) were finally analysed. Six months after the start of treatment, 8/20 (40%) patients responded-2 complete (CR) and 6 partial responses (PR). At the end of 1 year; 2 patients maintained CR and seven patients continued PR (overall responders 45%). The response was better in SAA (54.5%) with 2 CR and 4 PR; than in VSAA (33%) with 3 PR . Eleven (55%) children were alive without response. One patient developed AML 13 months later.

Conclusion: We conclude that antithymocyte globulin and cyclosporin combination is an effective treatment for aplastic anemia patients who are ineligible for bone marrow transplantation.

Citing Articles

A Systematic Review and Meta-Analysis of Eltrombopag Efficacy Combined With Immunosuppressive Drugs in Treatment of Severe Aplastic Anemia.

Illango J, Seffah K, Naveen N, Paudel Y, Patel A, Pachchipulusu V Cureus. 2024; 16(8):e65970.

PMID: 39221321 PMC: 11365712. DOI: 10.7759/cureus.65970.

Idiopathic Aplastic anemia: Indian Perspective.

Dolai T, Jain M, Mahapatra M Indian J Hematol Blood Transfus. 2023; 39(3):357-370.

PMID: 37304471 PMC: 10247658. DOI: 10.1007/s12288-022-01592-4.

Immunosuppressive therapy for aplastic anemia: a single-center experience from western India.

Shah S, Jain P, Shah K, Patel K, Parikh S, Patel A Ann Hematol. 2018; 98(1):41-46.

PMID: 30173288 PMC: 6334724. DOI: 10.1007/s00277-018-3487-2.

Safety and efficacy of indigenous equine antithymocyte globulin along with cyclosporine in subjects with acquired aplastic anemia.

Agarwal M, Jijina F, Shah S, Malhotra P, Damodar S, Ross C Indian J Hematol Blood Transfus. 2015; 31(2):174-9.

PMID: 25825555 PMC: 4375142. DOI: 10.1007/s12288-014-0423-z.

Cytogenetic profile of aplastic anaemia in Indian children.

Gupta V, Kumar A, Saini I, Saxena A Indian J Med Res. 2013; 137(3):502-6.

PMID: 23640556 PMC: 3705657.

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