A 5-year-old Girl with a Congenital Ganglioneuroma Diagnosed by Fine Needle Aspiration Biopsy: a Case Report
Overview
Authors
Affiliations
Introduction: Ganglioneuroma is a rare, benign, neuroblastic tumor arising mainly from the central or peripheral autonomic nervous system, especially the sympathetic system. The most affected anatomical sites are the posterior mediastinum, retroperitoneum, adrenal gland and head and neck soft tissue. In the current literature, reports of ganglioneuroma diagnosed by fine-needle aspiration and its cytological appearance are scarce.
Case Presentation: A 5-year-old girl presented with a mass in the cervical region since birth. Laboratory routine tests were within normal limits, ultrasonography demonstrated a solid and well-circumscribed lesion in the soft tissues of the cervical region. Fine needle aspiration biopsy was carried out, and the obtained smears showed a mixture of mature ganglion cells and groups of spindle cells suggestive of schwann cell origin. A diagnosis of ganglioneuroma was suggested. Core biopsy and surgical resection confirmed this diagnosis.
Conclusion: Congenital ganglioneuroma of the cervical region is an uncommon soft tissue benign neoplasm of neuroblastic origin, and it should be considered in the differential diagnosis of head and neck pediatric soft tissue tumors. Fine needle aspiration biopsy technique is a reliable method that can be used with confidence when dealing with pediatric soft tissue tumors.
Gasparini A, Jiang S, Mani R, Tatta T, Gallo O Cancers (Basel). 2024; 16(20).
PMID: 39456586 PMC: 11506046. DOI: 10.3390/cancers16203492.
Corrado S, Morgante C, Tassi S, Maccarrone F, Di Massa G, Pontecorvi A Int J Endocrinol Metab. 2023; 21(2):e126486.
PMID: 37662645 PMC: 10474842. DOI: 10.5812/ijem-126486.
A Case of Recurrent Urinary Tract Infections With Neurogenic Bladder Due to Spinal Tumors.
Naseri M, Ashrafzadeh F, Faraji Rad M, Sharifi N Iran J Child Neurol. 2021; 15(1):119-124.
PMID: 33558821 PMC: 7856431. DOI: 10.22037/ijcn.v15i2.27793.
Anterior neck swelling in a child: Cytological consideration of an uncommon diagnosis.
Raghav S, Gupta P, Ahuja A, Bhardwaj M Cytojournal. 2019; 16:7.
PMID: 31031817 PMC: 6444900. DOI: 10.4103/cytojournal.cytojournal_17_18.
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P BMC Cancer. 2016; 16:542.
PMID: 27465021 PMC: 4964292. DOI: 10.1186/s12885-016-2513-9.