Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

Overview

Journal Cell Stem Cell

Publisher Cell Press

Specialty Cell Biology

Date 2008 Mar 29

PMID 18371417

Citations 63

Authors

Paul S Knoepfler

Affiliations

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Abstract

Screening cocktails of candidate genes for induction of pluripotency and self-renewal in nonstem cells has identified a surprising new embryonic stem cell regulator, the myc proto-oncogene. Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed.

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