Vitamin D Deficiency, Cardiac Iron and Cardiac Function in Thalassaemia Major

Overview

Journal Br J Haematol

Specialty Hematology

Date 2008 Mar 29

PMID 18371108

Citations 22

Authors

John C Wood

Susan Claster

Susan Carson

J D Menteer

Thomas Hofstra

Rachna Khanna

Thomas Coates

Affiliations

Soon will be listed here.

Abstract

Vitamin D25-OH and D1-25OH levels were compared with cardiac R2* (1/T2*), left ventricular ejection fraction (LVEF), age, ferritin and liver iron in 24 thalassaemia major patients. Vitamin D25-OH levels were reduced in 13/24 patients while vitamin D1-25OH levels were often elevated. Vitamin D25-OH levels decreased with age (r(2) = 0.48) and with liver iron (r(2) = 0.20). Cardiac R2* was inversely related with the ratio of D25-OH to D1-25OH levels (r(2) = 0.42). LVEF was also proportional to the D25-OH/D1-25OH ratio (r(2) = 0.49). Vitamin D deficiency may be associated with cardiac iron uptake and ventricular dysfunction in thalassaemia major patients.

Citing Articles

A Comparison between Serum 25-Hydroxyvitamin D3 Levels and Serum Ferritin in Children and Adolescents with Iron Deficiency Anemia, Thalassemia Minor, Thalassemia Major and Healthy People.

Hemmatipour A, Kikhaei B, Jalkani R, Ahmadnejad M, Soleimanzadeh F, Rokhafrooz D Iran J Public Health. 2024; 53(6):1394-1403.

PMID: 39430154 PMC: 11488545.

Low Vitamin D Levels Are Associated with Increased Cardiac Iron Uptake in Beta-Thalassemia Major.

Meloni A, Pistoia L, Vassalle C, Spasiano A, Fotzi I, Bagnato S Diagnostics (Basel). 2023; 13(24).

PMID: 38132240 PMC: 10742632. DOI: 10.3390/diagnostics13243656.

Cardiac complications in thalassemia throughout the lifespan: Victories and challenges.

Wood J Ann N Y Acad Sci. 2023; 1530(1):64-73.

PMID: 37902424 PMC: 10841366. DOI: 10.1111/nyas.15078.

Iron as a therapeutic target in chronic liver disease.

Kouroumalis E, Tsomidis I, Voumvouraki A World J Gastroenterol. 2023; 29(4):616-655.

PMID: 36742167 PMC: 9896614. DOI: 10.3748/wjg.v29.i4.616.

Iron-Induced Hepatocarcinogenesis-Preventive Effects of Nutrients.

Tsuchiya H Front Oncol. 2022; 12:940552.

PMID: 35832553 PMC: 9271801. DOI: 10.3389/fonc.2022.940552.

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