MGluR1/5-dependent Long-term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2008 Mar 28

PMID 18367087

Citations 77

Authors

Richard W Cho

Joo Min Park

Steffen B E Wolff

Desheng Xu

Carsten Hopf

Jin-Ah Kim

Radhika C Reddy

Ronald S Petralia

Mark S Perin

David J Linden

Paul F Worley

Affiliations

Soon will be listed here.

Abstract

Matrix metalloproteases (MMPs) play a role in remodeling the extracellular matrix during brain development and have been implicated in synaptic plasticity. Here, we report that a member of the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR), undergoes regulated cleavage by the MMP tumor necrosis factor-alpha converting enzyme (TACE). NPR is enriched at excitatory synapses where it associates with AMPA-type glutamate receptors (AMPAR) and enhances synaptogenesis. However, in response to activation of group 1 mGluRs (mGluR1/5), TACE cleaves NPR and releases the pentraxin domain from its N-terminal transmembrane domain. Cleaved NPR rapidly accumulates in endosomes where it colocalizes with AMPAR. This process is necessary for mGluR1/5-dependent LTD in hippocampal and cerebellar synapses. These observations suggest that cleaved NPR functions to "capture" AMPAR for endocytosis and reveal a bifunctional role of NPs in both synapse strengthening and weakening.

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