Nonalcoholic Fatty Liver Disease: Diagnosis and Relation to Metabolic Syndrome and Approach to Treatment

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2008 Mar 28

PMID 18366995

Citations 13

Authors

Steven D Lidofsky

Affiliations

Soon will be listed here.

Abstract

Nonalcoholic fatty liver disease is an increasingly prevalent disorder that spans a range of conditions from hepatic steatosis to cirrhosis. It is commonly associated with obesity and diabetes, two components of the metabolic syndrome. Although hepatic steatosis may be reversible, disease progression appears to be triggered by overproduction of reactive oxygen species and mitochondrial injury in hepatocytes. Evolving treatments are focused on reversing insulin resistance, which underlies many of the metabolic derangements in this disease.

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