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Spinal Cord Compression in Cancer Patients: Review of Diagnosis and Treatment

Overview
Journal Curr Oncol Rep
Publisher Current Science
Specialty Oncology
Date 2008 Mar 28
PMID 18366964
Citations 8
Authors
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Abstract

Spinal cord compression (SCC) is a well-known complication in cancer patients, with an enormous potential impact on quality of life. In most cases, treatment is palliative, but a prompt diagnosis and immediate treatment is essential to preserving neurological function. Whereas steroids and radiation have been the mainstay of therapy for many years, the role and timing of surgery has remained controversial. However, class I evidence now exists to support the benefit of pre-irradiation surgical decompression in a carefully selected subpopulation of patients with SCC. A multidisciplinary approach is required to maximize the therapeutic and functional outcome of these patients.

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References
1.
GREENBERG H, Kim J, Posner J . Epidural spinal cord compression from metastatic tumor: results with a new treatment protocol. Ann Neurol. 1980; 8(4):361-6. DOI: 10.1002/ana.410080404. View

2.
Abrahm J . Assessment and treatment of patients with malignant spinal cord compression. J Support Oncol. 2004; 2(5):377-88, 391. View

3.
Helweg-Larsen S, Sorensen P, Kreiner S . Prognostic factors in metastatic spinal cord compression: a prospective study using multivariate analysis of variables influencing survival and gait function in 153 patients. Int J Radiat Oncol Biol Phys. 2000; 46(5):1163-9. DOI: 10.1016/s0360-3016(99)00333-8. View

4.
Fourney D, Schomer D, Nader R, Chlan-Fourney J, Suki D, Ahrar K . Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg. 2003; 98(1 Suppl):21-30. DOI: 10.3171/spi.2003.98.1.0021. View

5.
Gilbert R, Kim J, Posner J . Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol. 1978; 3(1):40-51. DOI: 10.1002/ana.410030107. View