Histone Deacetylase Inhibitors Protect Against and Mitigate the Lethality of Total-body Irradiation in Mice

Overview

Journal Radiat Res

Specialties Genetics
Radiology

Date 2008 Mar 28

PMID 18363436

Citations 14

Authors

Stephen L Brown

Andrew Kolozsvary

Jianguo Liu

Samuel Ryu

Jae Ho Kim

Affiliations

Soon will be listed here.

Abstract

It was hypothesized that histone deacetylase (HDAC) inhibitors may increase survival after total-body irradiation (TBI) based on previous reports demonstrating that HDAC inhibitors stimulate the proliferation of bone marrow stem cells. Using the time for mice to lose 20% or more of their weight as the end point, two HDAC inhibitors, valproic acid and trichostatin-A, were found to reduce lethality in a dose-dependent manner. HDAC inhibitors were effective at reducing lethality when given either 24 h before or 1 h after TBI. The results indicate that HDAC inhibitors have potential for protecting against and mitigating radiation-induced lethality.

Citing Articles

The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.

Liu G, Lim D, Cai Z, Ding W, Tian Z, Dong C Front Oncol. 2021; 11:646256.

PMID: 33842359 PMC: 8029989. DOI: 10.3389/fonc.2021.646256.

Histone Deacetylase Inhibitor Induced Radiation Sensitization Effects on Human Cancer Cells after Photon and Hadron Radiation Exposure.

Gerelchuluun A, Maeda J, Manabe E, Brents C, Sakae T, Fujimori A Int J Mol Sci. 2018; 19(2).

PMID: 29414878 PMC: 5855718. DOI: 10.3390/ijms19020496.

Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma.

Watanabe S, Kuwabara Y, Suehiro S, Yamashita D, Tanaka M, Tanaka A Eur J Clin Pharmacol. 2016; 73(3):357-363.

PMID: 27889835 DOI: 10.1007/s00228-016-2167-1.

Opportunities and challenges of radiotherapy for treating cancer.

Schaue D, McBride W Nat Rev Clin Oncol. 2015; 12(9):527-40.

PMID: 26122185 PMC: 8396062. DOI: 10.1038/nrclinonc.2015.120.

Radioprotective effects of valproic acid, a histone deacetylase inhibitor, in the rat brain.

Zhou Y, Niu J, Li S, Hou H, Xu Y, Zhang W Biomed Rep. 2014; 3(1):63-69.

PMID: 25469249 PMC: 4251104. DOI: 10.3892/br.2014.367.

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