Intracellular Devastation in Heart Failure

Overview

Journal Heart Fail Rev

Date 2008 Mar 19

PMID 18347978

Citations 20

Authors

Federica Del Monte

Roger J Hajjar

Affiliations

Soon will be listed here.

Abstract

End-stage heart failure is characterized by a number of abnormalities at the cellular level, which include changes in excitation-contraction coupling, alterations in contractile proteins and activation/deactivation of signaling pathways. Even though many of these changes are adaptive to the high workload and stress in heart failure, a significant number of these alterations are deeply deleterious to the cardiac cell. In this article, we will review the changes in calcium cycling that occur in myopathic hearts and how they can be effectively targeted. We will also focus on protein misfolding in the setting of cardiac dysfunction.

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References

Beuckelmann D, Erdmann E . Ca(2+)-currents and intracellular [Ca2+]i-transients in single ventricular myocytes isolated from terminally failing human myocardium. Basic Res Cardiol. 1992; 87 Suppl 1:235-43. DOI: 10.1007/978-3-642-72474-9_19. View

Schillinger W, Lehnart S, Prestle J, Preuss M, Pieske B, Maier L . Influence of SR Ca(2+)-ATPase and Na(+)-Ca(2+)-exchanger on the force-frequency relation. Basic Res Cardiol. 1998; 93 Suppl 1:38-45. DOI: 10.1007/s003950050208. View

James P, Pfund C, Craig E . Functional specificity among Hsp70 molecular chaperones. Science. 1997; 275(5298):387-9. DOI: 10.1126/science.275.5298.387. View

Hasenfuss G, Reinecke H, Studer R, Pieske B, Meyer M, Drexler H . Calcium cycling proteins and force-frequency relationship in heart failure. Basic Res Cardiol. 1996; 91 Suppl 2:17-22. DOI: 10.1007/BF00795357. View

Gwathmey J, Hajjar R . Relation between steady-state force and intracellular [Ca2+] in intact human myocardium. Index of myofibrillar responsiveness to Ca2+. Circulation. 1990; 82(4):1266-78. DOI: 10.1161/01.cir.82.4.1266. View

Winslow R, Rice J, Jafri S . Modeling the cellular basis of altered excitation-contraction coupling in heart failure. Prog Biophys Mol Biol. 1998; 69(2-3):497-514. DOI: 10.1016/s0079-6107(98)00022-4. View

Verkhratsky A, Toescu E . Endoplasmic reticulum Ca(2+) homeostasis and neuronal death. J Cell Mol Med. 2004; 7(4):351-61. PMC: 6740085. DOI: 10.1111/j.1582-4934.2003.tb00238.x. View

Schmidt U, Hajjar R, Helm P, Kim C, Doye A, Gwathmey J . Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure. J Mol Cell Cardiol. 1998; 30(10):1929-37. DOI: 10.1006/jmcc.1998.0748. View

Benjamin I, MCMILLAN D . Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ Res. 1998; 83(2):117-32. DOI: 10.1161/01.res.83.2.117. View

10.

Hasenfuss G, Pieske B . Calcium cycling in congestive heart failure. J Mol Cell Cardiol. 2002; 34(8):951-69. DOI: 10.1006/jmcc.2002.2037. View

11.

Petersen O, Burdakov D, Tepikin A . Regulation of store-operated calcium entry: lessons from a polarized cell. Eur J Cell Biol. 1999; 78(4):221-3. DOI: 10.1016/s0171-9335(99)80054-5. View

12.

Schmitt J, Kamisago M, Asahi M, Li G, Ahmad F, Mende U . Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science. 2003; 299(5611):1410-3. DOI: 10.1126/science.1081578. View

13.

Neumann J, Eschenhagen T, Jones L, Linck B, Schmitz W, Scholz H . Increased expression of cardiac phosphatases in patients with end-stage heart failure. J Mol Cell Cardiol. 1997; 29(1):265-72. DOI: 10.1006/jmcc.1996.0271. View

14.

Gwathmey J, Copelas L, Mackinnon R, Schoen F, Feldman M, Grossman W . Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res. 1987; 61(1):70-6. DOI: 10.1161/01.res.61.1.70. View

15.

Brixius K, Mehlhorn U, Bloch W, Kranias E, Schwinger R . Increased Ca2+-sensitivity of myofibrillar tension in heart failure and its functional implication. Basic Res Cardiol. 2002; 97 Suppl 1:I111-7. DOI: 10.1007/s003950200039. View

16.

Nishizawa J, Nakai A, Higashi T, Tanabe M, Nomoto S, Matsuda K . Reperfusion causes significant activation of heat shock transcription factor 1 in ischemic rat heart. Circulation. 1996; 94(9):2185-92. DOI: 10.1161/01.cir.94.9.2185. View

17.

Carr A, Schmidt A, Suzuki Y, Monte F, Sato Y, Lanner C . Type 1 phosphatase, a negative regulator of cardiac function. Mol Cell Biol. 2002; 22(12):4124-35. PMC: 133876. DOI: 10.1128/MCB.22.12.4124-4135.2002. View

18.

Brittsan A, Ginsburg K, Chu G, Yatani A, Wolska B, Schmidt A . Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport. Circ Res. 2003; 92(7):769-76. DOI: 10.1161/01.RES.0000066661.49920.59. View

19.

Pogwizd S, Bers D . Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med. 2004; 14(2):61-6. DOI: 10.1016/j.tcm.2003.12.002. View

20.

Haghighi K, Kolokathis F, Pater L, Lynch R, Asahi M, Gramolini A . Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest. 2003; 111(6):869-76. PMC: 153772. DOI: 10.1172/JCI17892. View