Bisphosphonate Treatment in Chronic Recurrent Multifocal Osteomyelitis

Overview

Journal J Pediatr

Specialty Pediatrics

Date 2008 Mar 19

PMID 18346517

Citations 35

Authors

Peter J Simm

Roger C Allen

Margaret R Zacharin

Affiliations

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Abstract

Objective: To test the safety and efficacy of biphosphonates in chronic recurrent multifocal osteomyelitis (CRMO).

Study Design: Five patients with CRMO, all of whom had ongoing pain and loss of function despite conventional treatment with non-steroidal anti-inflammatory agents, were treated with pamidronate (1 mg/kg/dose with a dosing frequency of 2 to 4 monthly for a total treatment duration of 12 to 42 months).

Results: Pain decreased after the first infusion for 4 of 5 patients, with symptomatic improvement maintained with time. Significant improvement was seen in radiological lesions for these 4 patients.

Conclusion: Bisphosphonates appear to be a useful and safe adjunctive treatment in CRMO when simple therapies such as anti-inflammatory agents fail to control symptoms or cases in which lesion expansion continues.

Citing Articles

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Howlader D, Daga D, Das A, Baisya R, Babaria B Calcif Tissue Int. 2025; 116(1):47.

PMID: 40055217 DOI: 10.1007/s00223-025-01354-0.

[Arthritis and osteomyelitis in childhood and adolescence-Bacterial and nonbacterial].

Hospach T, Kallinich T, Martin L, V Kalle T, Reichert F, Girschick H Z Rheumatol. 2024; .

PMID: 38653784 DOI: 10.1007/s00393-024-01504-z.

Chronic Nonbacterial Osteomyelitis in Inflammatory Bowel Disease.

Tzaneti A, Athanasopoulou E, Fessatou S, Fotis L Life (Basel). 2023; 13(12).

PMID: 38137947 PMC: 10745028. DOI: 10.3390/life13122347.

Treatment Effect of Zoledronic Acid in Chronic Non-bacterial Osteomyelitis of the Jaw: A Case Series.

Jansen R, Nilsson J, Buch-Larsen K, Kofod T, Schwarz P Calcif Tissue Int. 2023; 114(2):129-136.

PMID: 37991563 PMC: 10803718. DOI: 10.1007/s00223-023-01154-4.

Chronic nonbacterial monoarticular osteomyelitis of the elbow.

Salazar L, Cone R, Morrey B JSES Rev Rep Tech. 2023; 2(4):592-596.

PMID: 37588451 PMC: 10426514. DOI: 10.1016/j.xrrt.2022.06.001.