Tissue Pulsatility Imaging of Cerebral Vasoreactivity During Hyperventilation

Overview

Journal Ultrasound Med Biol

Specialty Radiology

Date 2008 Mar 14

PMID 18336991

Citations 12

Authors

John C Kucewicz

Barbrina Dunmire

Nicholas D Giardino

Daniel F Leotta

Marla Paun

Stephen R Dager

Kirk W Beach

Affiliations

Soon will be listed here.

Abstract

Tissue pulsatility imaging (TPI) is an ultrasonic technique that is being developed at the University of Washington to measure tissue displacement or strain as a result of blood flow over the cardiac and respiratory cycles. This technique is based in principle on plethysmography, an older nonultrasound technology for measuring expansion of a whole limb or body part due to perfusion. TPI adapts tissue Doppler signal processing methods to measure the "plethysmographic" signal from hundreds or thousands of sample volumes in an ultrasound image plane. This paper presents a feasibility study to determine if TPI can be used to assess cerebral vasoreactivity. Ultrasound data were collected transcranially through the temporal acoustic window from four subjects before, during and after voluntary hyperventilation. In each subject, decreases in tissue pulsatility during hyperventilation were observed that were statistically correlated with the subject's end-tidal CO2 measurements. (

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