Markers of Collagen and Basement Membrane Metabolism in Sera of Patients with Progressive Systemic Sclerosis

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1991 Jul 1

PMID 1831604

Citations 4

Authors

N G Guseva

N V Anikina

R Myllyla

L Risteli

J Risteli

J V Chochlova

K I Kivirikko

V A Nassonova

Affiliations

Soon will be listed here.

Abstract

The concentrations of the amino terminal propeptide of type III procollagen, the 7S domain of type IV collagen, and the fragment P1 of laminin (PIIINP, 7S, and P1 respectively) and the activity of galactosylhydroxylysyl glucosyltransferase (GGT) in serum were evaluated as indicators of disease activity in a cross sectional study of 84 patients with progressive systemic sclerosis. The mean values of PIIINP, P1, and GGT were raised in progressive systemic sclerosis, 19-32% of patients having abnormal values of the various tests. PIIINP, measured with two different assays, and P1 were associated with active, acute, or subacute disease. GGT also correlated positively with some acute phase proteins in the whole group, without a clear association with the course of the disease. Arthritis was associated with increased PIIINP concentrations as well as with an increased activity of GGT. Kidney disease led to raised concentrations of the degradation products of PIIINP. Raynaud's phenomenon in the hands was related to increased PIIINP concentrations.

Citing Articles

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Homocysteine and laminin are not prognostic markers in patients with septic inflammatory response syndrome.

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Serum laminin in malaria.

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References

Horslev-Petersen K, Ammitzboll T, Engstrom-Laurent A, Bentsen K, Junker P, ASBOE-HANSEN G . Serum and urinary aminoterminal type III procollagen peptide in progressive systemic sclerosis: relationship to sclerodermal involvement, serum hyaluronan and urinary collagen metabolites. J Rheumatol. 1988; 15(3):460-7. View

Horslev-Petersen K, Bentsen K, Engstrom-Laurent A, Junker P, Halberg P, Lorenzen I . Serum amino terminal type III procollagen peptide and serum hyaluronan in rheumatoid arthritis: relation to clinical and serological parameters of inflammation during 8 and 24 months' treatment with levamisole, penicillamine, or azathioprine. Ann Rheum Dis. 1988; 47(2):116-26. PMC: 1003463. DOI: 10.1136/ard.47.2.116. View

Myllyla R, Risteli L, Kivirikko K . Collagen glucosyltransferase. Partial purification and characterization of the enzyme from whole chick embryos and chick-embryo cartilage. Eur J Biochem. 1976; 61(1):59-67. DOI: 10.1111/j.1432-1033.1976.tb09997.x. View

Majewski S, Skiendzielewska A, Makiela B, Jablonska S, Blaszczyk M . Serum levels of type III collagen aminopropeptide in patients with systemic scleroderma. Arch Dermatol Res. 1987; 279(7):484-6. DOI: 10.1007/BF00412596. View

Risteli L, Risteli J . Analysis of extracellular matrix proteins in biological fluids. Methods Enzymol. 1987; 145:391-411. DOI: 10.1016/0076-6879(87)45022-2. View

Jimenez S, Feldman G, BASHEY R, Bienkowski R, Rosenbloom J . Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts. Biochem J. 1986; 237(3):837-43. PMC: 1147064. DOI: 10.1042/bj2370837. View

Krieg T, Langer I, Gerstmeier H, Keller J, Mensing H, Goerz G . Type III collagen aminopropeptide levels in serum of patients with progressive systemic scleroderma. J Invest Dermatol. 1986; 87(6):788-91. DOI: 10.1111/1523-1747.ep12459865. View

Niemela O, Risteli L, Sotaniemi E, Risteli J . Type IV collagen and laminin-related antigens in human serum in alcoholic liver disease. Eur J Clin Invest. 1985; 15(3):132-7. DOI: 10.1111/j.1365-2362.1985.tb00156.x. View

Bentsen K, Henriksen J, Bendtsen F, Horslev-Petersen K, Lorenzen I . Splanchnic and renal extraction of circulating type III procollagen aminoterminal propeptide in patients with normal liver function and in patients with alcoholic cirrhosis. Hepatology. 1990; 11(6):957-63. DOI: 10.1002/hep.1840110608. View

10.

Rohde H, Bruckner P, Timpl R . Immunochemical properties of the aminopropeptide of procollagen type III. Eur J Biochem. 1983; 135(2):197-202. DOI: 10.1111/j.1432-1033.1983.tb07637.x. View

11.

Black C, Duance V, Sims T, Light N . An investigation of the biochemical and histological changes in the collagen of the kidney and skeletal muscle in systemic sclerosis. Coll Relat Res. 1983; 3(3):231-43. DOI: 10.1016/s0174-173x(83)80006-5. View

12.

Kahari V, Vuorio T, Nanto-Salonen K, Vuorio E . Increased type I collagen mRNA levels in cultured scleroderma fibroblasts. Biochim Biophys Acta. 1984; 781(1-2):183-6. DOI: 10.1016/0167-4781(84)90136-2. View

13.

Rohde H, Langer I, Krieg T, Timpl R . Serum and urine analysis of the aminoterminal procollagen peptide type III by radioimmunoassay with antibody Fab fragments. Coll Relat Res. 1983; 3(5):371-9. DOI: 10.1016/s0174-173x(83)80018-1. View

14.

Wallenstein S, Zucker C, Fleiss J . Some statistical methods useful in circulation research. Circ Res. 1980; 47(1):1-9. DOI: 10.1161/01.res.47.1.1. View

15.

. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum. 1980; 23(5):581-90. DOI: 10.1002/art.1780230510. View

16.

Rohde H, Vargas L, Hahn E, KALBFLEISCH H, Bruguera M, Timpl R . Radioimmunoassay for type III procollagen peptide and its application to human liver disease. Eur J Clin Invest. 1979; 9(6):451-9. DOI: 10.1111/j.1365-2362.1979.tb00912.x. View

17.

FLEISCHMAJER R, Gay S, Meigel W, Perlish J . Collagen in the cellular and fibrotic stages of scleroderma. Arthritis Rheum. 1978; 21(4):418-28. DOI: 10.1002/art.1780210404. View

18.

FLEISCHMAJER R . The pathophysiology of scleroderma. Int J Dermatol. 1977; 16(5):310-8. DOI: 10.1111/j.1365-4362.1977.tb00747.x. View

19.

Anttinen H . Collagen glucosyltransferases activity in human serum. Clin Chim Acta. 1977; 77(3):323-30. DOI: 10.1016/0009-8981(77)90236-4. View

20.

Winkelmann R . Pathogenesis and staging of scleroderma. Acta Derm Venereol. 1976; 56(2):83-92. View