Ventricular-vascular Interaction in Heart Failure

Overview

Journal Heart Fail Clin

Specialty Cardiology & Vascular Diseases

Date 2008 Mar 4

PMID 18313622

Citations 117

Authors

Barry A Borlaug

David A Kass

Affiliations

Soon will be listed here.

Abstract

Nearly half of all patients who have heart failure have preserved ejection fraction (HFpEF). Patients who have HFpEF tend to be older, female, and hypertensive, and characteristically display increased ventricular and arterial stiffening. In this article, we discuss the pathophysiology of abnormal ventriculoarterial stiffening and how it affects ventricular function, cardiovascular hemodynamics, reserve capacity, and symptoms. We conclude by exploring how novel treatment strategies targeting abnormal ventricular-arterial interaction might prove useful in the treatment of patients who have HFpEF.

Citing Articles

Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF.

Li J, Slocum C, Sbarbaro J, Schoenike M, Campain J, Prasad C JACC Adv. 2024; 3(8):101101.

PMID: 39105119 PMC: 11299572. DOI: 10.1016/j.jacadv.2024.101101.

Identifying the Mechanisms of a Peripherally Limited Exercise Phenotype in Patients With Heart Failure With Preserved Ejection Fraction.

Skow R, Sarma S, MacNamara J, Bartlett M, Wakeham D, Martin Z Circ Heart Fail. 2024; 17(8):e011693.

PMID: 39051098 PMC: 11335445. DOI: 10.1161/CIRCHEARTFAILURE.123.011693.

Reduced dynamic changes in pulmonary artery compliance during isometric handgrip exercise in patients with heart failure.

Hashemi D, Hou X, Doeblin P, Weiss J, Beyer R, Neye M Sci Rep. 2024; 14(1):15594.

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Update on the Use of Pulse Wave Velocity to Measure Age-Related Vascular Changes.

Marshall A, Neikirk K, Afolabi J, Mwesigwa N, Shao B, Kirabo A Curr Hypertens Rep. 2023; 26(3):131-140.

PMID: 38159167 PMC: 10955453. DOI: 10.1007/s11906-023-01285-x.

Change in Systemic Arterial Pulsatility Index (SAPi) during Heart Failure Hospitalization is Associated with Improved Outcomes.

Lin E, Boadu A, Skeiky N, Mehta N, Kwon Y, Breathett K Am Heart J Plus. 2023; 27.

PMID: 38107611 PMC: 10723636. DOI: 10.1016/j.ahjo.2023.100275.

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