Alteration of the Relative Levels of INKT Cell Subsets is Associated with Chronic Mycobacterial Infections

Overview

Journal Clin Immunol

Specialty Allergy & Immunology

Date 2008 Mar 1

PMID 18308638

Citations 31

Authors

Jin S Im

Tae-Jin Kang

Seong-Beom Lee

Chi-Hong Kim

Sang-Haak Lee

Manjunatha M Venkataswamy

Evan R Serfass

Bing Chen

Petr A Illarionov

Gurdyal S Besra

William R Jacobs Jr

Gue-Tae Chae

Steven A Porcelli

Affiliations

Soon will be listed here.

Abstract

CD1d-restricted invariant natural killer T cells (iNKT cells) have been identified as an important type of effector and regulatory T cell, but their roles in the chronic infectious diseases caused by Mycobacterium tuberculosis and Mycobacterium leprae remain poorly defined. Here, we studied circulating human iNKT cells in blood samples from tuberculosis (TB) and leprosy patients. We found that the percentages of iNKT cells among total circulating T cells in TB and leprosy patients were not significantly different from those in normal controls. However, both TB and leprosy patients showed a selective reduction of the proinflammatory CD4(-)CD8beta(-) (DN) iNKT cells with a proportionate increase in the CD4(+) iNKT cells. Similar phenotypic alterations in circulating iNKT cells were observed in a mouse model of M. tuberculosis infection. Taken together, these findings indicate that the selective reduction of circulating DN iNKT cells is associated with chronic infections caused by M. tuberculosis and M. leprae.

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