Genome-wide Scan and Fine-mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2008 Feb 29

PMID 18304493

Citations 17

Authors

Axel M Hillmer

Antonia Flaquer

Sandra Hanneken

Sibylle Eigelshoven

Anne-Katrin Kortum

Felix F Brockschmidt

Astrid Golla

Christine Metzen

Holger Thiele

Susanne Kolberg

Roman Reinartz

Regina C Betz

Thomas Ruzicka

Hans Christian Hennies

Roland Kruse

Markus M Nothen

Affiliations

Soon will be listed here.

Abstract

Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.

Citing Articles

Relationship of Hypothyroidism with Alopecia Areata and Androgenetic Alopecia: Insights from a Two-Sample Mendelian Randomization Study.

Zhang G, Huang X, Li H, Gong H, Zhou Y, Liu F Clin Cosmet Investig Dermatol. 2024; 17:1865-1874.

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Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles.

Herrera-Rivero M, Hochfeld L, Sivalingam S, Nothen M, Heilmann-Heimbach S BMC Dermatol. 2020; 20(1):16.

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Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort.

Ding Q, Xu Y, Sun W, Liu J, Deng Y, Wu Q J Int Med Res. 2020; 48(3):300060519897190.

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Androgenetic Alopecia: Relationship to Anthropometric Indices, Blood Pressure and Life-Style Habits.

Danesh-Shakiba M, Poorolajal J, Alirezaei P Clin Cosmet Investig Dermatol. 2020; 13:137-143.

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Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia.

Rhie A, Son H, Kwak S, Lee S, Kim D, Lew B PLoS One. 2019; 14(9):e0222533.

PMID: 31525235 PMC: 6746394. DOI: 10.1371/journal.pone.0222533.

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