Sixty-four-section CT Cerebral Perfusion Evaluation in Patients with Carotid Artery Stenosis Before and After Stenting with a Cerebral Protection Device

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2008 Feb 26

PMID 18296553

Citations 6

Authors

F Gaudiello

V Colangelo

F Bolacchi

M Melis

R Gandini

F G Garaci

V Cozzolino

R Floris

G Simonetti

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Brain tissue viability depends on cerebral blood flow (CBF) that has to be kept within a narrow range to avoid the risk of developing ischemia. The aim of the study was to evaluate by 64-section CT (VCT) the cerebral perfusion modifications in patients with severe carotid stenosis before and after undergoing carotid artery stent placement (CAS) with a cerebral protection system.

Materials And Methods: Fifteen patients with unilateral internal carotid stenosis (>or=70%) underwent brain perfusional VCT (PVCT) 5 days before and 1 week after the stent-placement procedure. CBF and mean transit time (MTT) values were measured.

Results: Decreased CBF and increased MTT values were observed in the cerebral areas supplied by the stenotic artery as compared with the areas supplied by the contralateral patent artery (P < .001). A significant normalization of the perfusion parameters was observed after the stent-placement procedure (mean pretreatment MTT value, 5.3 +/- 0.2; mean posttreatment MTT value, 4.3 +/- 0.18, P < .001; mean pretreatment CBF value, 41.2 mL/s +/- 2.1; mean posttreatment CBF value, 47.9 mL/s +/- 2.9, P < .001).

Conclusions: PVCT is a useful technique for the assessment of the hemodynamic modifications in patients with severe carotid stenosis. The quantitative evaluation of cerebral perfusion makes it a reliable tool for the follow-up of patients who undergo CAS.

Citing Articles

Multiple blood flow measurements before and after carotid artery stenting via phase-contrast magnetic resonance imaging: An observational study.

Tanaka H, Watanabe Y, Nakamura H, Takahashi H, Arisawa A, Fujiwara T PLoS One. 2018; 13(4):e0195099.

PMID: 29641548 PMC: 5895018. DOI: 10.1371/journal.pone.0195099.

Carotid Artery Stenting and Blood-Brain Barrier Permeability in Subjects with Chronic Carotid Artery Stenosis.

Szarmach A, Halena G, Kaszubowski M, Piskunowicz M, Studniarek M, Lass P Int J Mol Sci. 2017; 18(5).

PMID: 28481312 PMC: 5454921. DOI: 10.3390/ijms18051008.

Role of Extracranial Carotid Duplex and Computed Tomography Perfusion Scanning in Evaluating Perfusion Status of Pericarotid Stenting.

Lin C, Chang Y, Liu C, Yu C, Lu H Biomed Res Int. 2016; 2016:7051856.

PMID: 27051669 PMC: 4802025. DOI: 10.1155/2016/7051856.

Haemodynamic alterations in cerebral blood vessels after carotid artery revascularisation: quantitative analysis using 2D phase-contrast MRI.

Youn S, Kim H, Do Y, Do J, Kwon O, Lee N Eur Radiol. 2013; 23(10):2880-90.

PMID: 23732686 DOI: 10.1007/s00330-013-2899-6.

Near-infrared transillumination back scattering sounding--new method to assess brain microcirculation in patients with chronic carotid artery stenosis.

Frydrychowski A, Winklewski P, Szarmach A, Halena G, Bandurski T PLoS One. 2013; 8(4):e61936.

PMID: 23613977 PMC: 3629110. DOI: 10.1371/journal.pone.0061936.

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