Intestinal Alkaline Phosphatase is a Gut Mucosal Defense Factor Maintained by Enteral Nutrition

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2008 Feb 23

PMID 18292227

Citations 159

Authors

Ross F Goldberg

William G Austen Jr

Xiaobo Zhang

Gitonga Munene

Golam Mostafa

Shaluk Biswas

Michael McCormack

Kyle R Eberlin

John T Nguyen

Hamit S Tatlidede

H Shaw Warren

Sonoko Narisawa

Jose L Millan

Richard A Hodin

Affiliations

Soon will be listed here.

Abstract

Under conditions of starvation and disease, the gut barrier becomes impaired, and trophic feeding to prevent gut mucosal atrophy has become a standard treatment of critically ill patients. However, the mechanisms responsible for the beneficial effects of enteral nutrition have remained a mystery. Using in vitro and in vivo models, we demonstrate that the brush-border enzyme, intestinal alkaline phosphatase (IAP), has the ability to detoxify lipopolysaccharide and prevent bacterial invasion across the gut mucosal barrier. IAP expression and function are lost with starvation and maintained by enteral feeding. It is likely that the IAP silencing that occurs during starvation is a key component of the gut mucosal barrier dysfunction seen in critically ill patients.

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