Nonmalignant Respiratory Effects of Chronic Arsenic Exposure from Drinking Water Among Never-smokers in Bangladesh

Overview

Journal Environ Health Perspect

Date 2008 Feb 22

PMID 18288317

Citations 52

Authors

Faruque Parvez

Yu Chen

Paul W Brandt-Rauf

Alfred Bernard

Xavier Dumont

Vesna Slavkovich

Maria Argos

Jeanine DArmiento

Robert Foronjy

M Rashidul Hasan

H E M Mahbubul Eunus

Joseph H Graziano

Habibul Ahsan

Affiliations

Soon will be listed here.

Abstract

Background: Arsenic from drinking water has been associated with malignant and nonmalignant respiratory illnesses. The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions.

Objectives: We examined the relationship of the serum level of Clara cell protein CC16--a novel biomarker for respiratory illnesses--with well As, total urinary As, and urinary As methylation indices.

Methods: We conducted a cross-sectional study in nonsmoking individuals (n = 241) selected from a large cohort with a wide range of As exposure (0.1-761 microg/L) from drinking water in Bangladesh. Total urinary As, urinary As metabolites, and serum CC16 were measured in urine and serum samples collected at baseline of the parent cohort study.

Results: We observed an inverse association between urinary As and serum CC16 among persons with skin lesions (beta = -0.13, p = 0.01). We also observed a positive association between secondary methylation index in urinary As and CC16 levels (beta = 0.12, p = 0.05) in the overall study population; the association was stronger among people without skin lesions (beta = 0.18, p = 0.04), indicating that increased methylation capability may be protective against As-induced respiratory damage. In a subsample of study participants undergoing spirometric measures (n = 31), we observed inverse associations between urinary As and predictive FEV(1) (forced expiratory volume measured in 1 sec) (r = -0.37; FEV(1)/forced vital capacity ratio and primary methylation index (r = -0.42, p = 0.01).

Conclusions: The findings suggest that serum CC16 may be a useful biomarker of epithelial lung damage in individuals with arsenical skin lesions. Also, we observed the deleterious respiratory effects of As exposure at concentrations lower than reported in earlier studies.

Citing Articles

Arsenic exposure is associated with elevated sweat chloride concentration and airflow obstruction among adults in Bangladesh: a cross sectional study.

Lee M, North C, Choudhuri I, Biswas S, Fleisch A, Farooque A medRxiv. 2024; .

PMID: 39399016 PMC: 11469388. DOI: 10.1101/2024.09.25.24314390.

Oral arsenite exposure induces inflammation and apoptosis in pulmonary tissue: acute and chronic evaluation in young and adult mice.

Pradhan S, Ali S, Rachamalla M, Niyogi S, Datusalia A Biometals. 2024; 37(3):587-607.

PMID: 38267778 DOI: 10.1007/s10534-023-00577-8.

Investigating the effect of myricetin against arsenic-induced cardiac toxicity in rats.

Aminzadeh A, Darijani M, Bashiri H Toxicol Res (Camb). 2023; 12(1):117-123.

PMID: 36866219 PMC: 9972817. DOI: 10.1093/toxres/tfad003.

Long-term exposure to low-level arsenic in drinking water is associated with cause-specific mortality and hospitalization in the Mt. Amiata area (Tuscany, Italy).

Nuvolone D, Stoppa G, Petri D, Voller F BMC Public Health. 2023; 23(1):71.

PMID: 36627610 PMC: 9832768. DOI: 10.1186/s12889-022-14818-x.

Elevated serum periostin levels among arsenic-exposed individuals and their associations with the features of asthma.

Tony S, Haque N, Siddique A, Khatun M, Rahman M, Islam Z Chemosphere. 2022; 298:134277.

PMID: 35278445 PMC: 9081271. DOI: 10.1016/j.chemosphere.2022.134277.

References

Smith A, Marshall G, Yuan Y, Ferreccio C, Liaw J, von Ehrenstein O . Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood. Environ Health Perspect. 2006; 114(8):1293-6. PMC: 1551995. DOI: 10.1289/ehp.8832. View

Berthoin K, Broeckaert F, Robin M, Haufroid V, de Burbure C, Bernard A . Serum pneumoproteins and biomarkers of exposure to urban air pollution: a cross-sectional comparison of policemen and foresters. Biomarkers. 2005; 9(4-5):341-52. DOI: 10.1080/13547500400018646. View

Hermans C, Petrek M, Kolek V, Weynand B, Pieters T, Lambert M . Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis. Eur Respir J. 2001; 18(3):507-14. DOI: 10.1183/09031936.01.99102601. View

Zaldivar R . A morbid condition involving cardio-vascular, broncho-pulmonary, digestive and neural lesions in children and young adults after dietary arsenic exposure. Zentralbl Bakteriol B Hyg Krankenhaushyg Betriebshyg Prav Med. 1980; 170(1-2):44-56. View

Rosenberg H . Systemic arterial disease and chronic arsenicism in infants. Arch Pathol. 1974; 97(6):360-5. View

Milton A, Hasan Z, Rahman A, Rahman M . Non-cancer effects of chronic arsenicosis in Bangladesh: preliminary results. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003; 38(1):301-5. DOI: 10.1081/ese-120016896. View

Zaldivar R, Ghai G . Clinical epidemiological studies on endemic chronic arsenic poisoning in children and adults, including observations on children with high- and low-intake of dietary arsenic. Zentralbl Bakteriol B Hyg Krankenhaushyg Betriebshyg Prav Med. 1980; 170(5-6):409-21. View

De B, Majumdar D, Sen S, Guru S, Kundu S . Pulmonary involvement in chronic arsenic poisoning from drinking contaminated ground-water. J Assoc Physicians India. 2005; 52:395-400. View

van Geen A, Ahsan H, Horneman A, Dhar R, Zheng Y, Hussain I . Promotion of well-switching to mitigate the current arsenic crisis in Bangladesh. Bull World Health Organ. 2002; 80(9):732-7. PMC: 2567605. View

10.

Chen Y, Factor-Litvak P, Howe G, Graziano J, Brandt-Rauf P, Parvez F . Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study. Am J Epidemiol. 2006; 165(5):541-52. DOI: 10.1093/aje/kwk037. View

11.

Menezes A, Perez-Padilla R, Jardim J, Muino A, Lopez M, Valdivia G . Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet. 2005; 366(9500):1875-81. DOI: 10.1016/S0140-6736(05)67632-5. View

12.

Johansson S, Keen C, Stahl A, Wennergren G, Benson M . Low levels of CC16 in nasal fluid of children with birch pollen-induced rhinitis. Allergy. 2005; 60(5):638-42. DOI: 10.1111/j.1398-9995.2005.00775.x. View

13.

Mazumder D, Haque R, Ghosh N, De B, Santra A, Chakraborti D . Arsenic in drinking water and the prevalence of respiratory effects in West Bengal, India. Int J Epidemiol. 2000; 29(6):1047-52. DOI: 10.1093/ije/29.6.1047. View

14.

Lantz R, Hays A . Role of oxidative stress in arsenic-induced toxicity. Drug Metab Rev. 2006; 38(4):791-804. DOI: 10.1080/03602530600980108. View

15.

Broeckaert F, Clippe A, Knoops B, Hermans C, Bernard A . Clara cell secretory protein (CC16): features as a peripheral lung biomarker. Ann N Y Acad Sci. 2001; 923:68-77. DOI: 10.1111/j.1749-6632.2000.tb05520.x. View

16.

Gioldassi X, Papadimitriou H, Mikraki V, Karamanos N . Clara cell secretory protein: determination of serum levels by an enzyme immunoassay and its importance as an indicator of bronchial asthma in children. J Pharm Biomed Anal. 2004; 34(4):823-6. DOI: 10.1016/S0731-7085(03)00570-3. View

17.

Broeckaert F, Bernard A . Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker. Clin Exp Allergy. 2000; 30(4):469-75. DOI: 10.1046/j.1365-2222.2000.00760.x. View

18.

Milton A, Rahman M . Respiratory effects and arsenic contaminated well water in Bangladesh. Int J Environ Health Res. 2002; 12(2):175-9. DOI: 10.1080/09603120220129346. View

19.

Saady J, Blanke R, Poklis A . Estimation of the body burden of arsenic in a child fatally poisoned by arsenite weedkiller. J Anal Toxicol. 1989; 13(5):310-2. DOI: 10.1093/jat/13.5.310. View

20.

BORGONO J, VICENT P, Venturino H, Infante A . Arsenic in the drinking water of the city of Antofagasta: epidemiological and clinical study before and after the installation of a treatment plant. Environ Health Perspect. 1977; 19:103-5. PMC: 1637404. DOI: 10.1289/ehp.19-1637404. View