Neuromotor Development and Mental Health at 5.5 Years of Age of Singletons Born at Term After Intracytoplasmatic Sperm Injection ICSI: Results of a Prospective Controlled Single-blinded Study in Germany

Overview

Journal Fertil Steril

Specialty Reproductive Medicine

Date 2008 Feb 19

PMID 18281037

Citations 9

Authors

Annika Ludwig

Alexander Katalinic

Ute Thyen

Alastair G Sutcliffe

Klaus Diedrich

Michael Ludwig

Affiliations

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Abstract

Objective: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI).

Design: Prospective controlled blinded study.

Setting: Tertiary care center.

Patient(s): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years.

Main Outcome Measure(s): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children.

Result(s): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence.

Conclusion(s): The ICSI children born at term develop normally, similar to SC children.

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