Role of Metformin in Patients with Polycystic Ovary Syndrome: the State of the Art

Overview

Journal Minerva Ginecol

Specialty Gynecology & Obstetrics

Date 2008 Feb 16

PMID 18277354

Citations 4

Authors

S Palomba

A Falbo

T Russo

F Orio

A Tollino

F Zullo

Affiliations

Soon will be listed here.

Abstract

Metformin, an insulin sensitizer widely used for the treatment of patients with type-2 diabetes mellitus (DM), was recently introduced in the clinical practice to treat women with polycystic ovary syndrome (PCOS). The aim of the current review was to evaluate the current role of metformin in the treatment of the PCOS-related disorders. The Authors analyze here the administration of metformin for treating the ovarian dysfunction due to PCOS, and show the evidences available in literature regarding its alternative uses.

Citing Articles

Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART.

E Puscheck E, Bolnick A, Awonuga A, Yang Y, Abdulhasan M, Li Q J Assist Reprod Genet. 2018; 35(8):1359-1366.

PMID: 29882092 PMC: 6086802. DOI: 10.1007/s10815-018-1213-6.

Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.

Unfer V, Facchinetti F, Orru B, Giordani B, Nestler J Endocr Connect. 2017; 6(8):647-658.

PMID: 29042448 PMC: 5655679. DOI: 10.1530/EC-17-0243.

Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress.

Bolnick A, Abdulhasan M, Kilburn B, Xie Y, Howard M, Andresen P J Assist Reprod Genet. 2017; 34(12):1609-1617.

PMID: 28913567 PMC: 5714821. DOI: 10.1007/s10815-017-1028-x.

Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos.

Bolnick A, Abdulhasan M, Kilburn B, Xie Y, Howard M, Andresen P J Assist Reprod Genet. 2016; 33(8):1027-39.

PMID: 27230877 PMC: 4974229. DOI: 10.1007/s10815-016-0735-z.