Genetics of Chronic Obstructive Pulmonary Disease

Overview

Journal Int J Chron Obstruct Pulmon Dis

Publisher Dove Medical Press

Specialty Pulmonary Medicine

Date 2008 Feb 14

PMID 18268927

Citations 14

Authors

Carola Seifart

Alexandra Plagens

Affiliations

Soon will be listed here.

Abstract

Chronic obstructive pulmonary disease (COPD) is a complex disease with multifactorial background, based on the interaction of environmental and genetic factors. Environmental factors are clearly related to the development of the disease. However, family and twin studies suggested genetics factors to be one of the important determinants for the development of COPD. Different approaches have been used to identify genes of interest. Genomewide linkage analysis found areas of interest on different chromosomes, with some genes located in this regions being identified and replicated as susceptibility genes. Numerous of candidate genes that could be linked to disease pathogenesis have been implicated in COPD genetics. However, the candidate gene approach is often limited by inconsistent results in other study populations. Recently, a combination of different methods is used giving more evidence for some candidate genes, including TGFbeta-1, Surfactant, SERPINE2 and microsomal epoxide hydrolase. In the future ongoing exact phenotype definition, combination of several approaches, genome-wide association studies and animal model genetics will lead to new insights into the genetics of COPD, with epigenetic factors needs to be further investigated and considered in concert with genetic findings.

Citing Articles

Impact of COVID-19 on Hospital Admissions for COPD Exacerbation: Lessons for Future Care.

Lawless M, Burgess M, Bourke S Medicina (Kaunas). 2022; 58(1).

PMID: 35056374 PMC: 8778793. DOI: 10.3390/medicina58010066.

Different Associations Between the Variants and Chronic Obstructive Pulmonary Disease Susceptibility.

Zeng Q, Chen Q, Zou D, Guo R, Xiao D, Jiang S Front Genet. 2020; 11:598053.

PMID: 33304392 PMC: 7701307. DOI: 10.3389/fgene.2020.598053.

High Serum Level of IL-17 in Patients with Chronic Obstructive Pulmonary Disease and the Alpha-1 Antitrypsin PiZ Allele.

Pervakova M, Mazing A, Lapin S, Tkachenko O, Budkova A, Surkova E Pulm Med. 2020; 2020:9738032.

PMID: 32089881 PMC: 7011399. DOI: 10.1155/2020/9738032.

Effect of the thymine-DNA glycosylase rs4135050 variant on Saudi smoker population.

Almutairi M, Mohammad Alhadeq A, Almeer R, Almutairi M, Alzahrani M, Semlali A Mol Genet Genomic Med. 2019; 7(4):e00590.

PMID: 30779328 PMC: 6465727. DOI: 10.1002/mgg3.590.

The Aryl Hydrocarbon Receptor and the Maintenance of Lung Health.

Guerrina N, Traboulsi H, Eidelman D, Baglole C Int J Mol Sci. 2018; 19(12).

PMID: 30563036 PMC: 6320801. DOI: 10.3390/ijms19123882.

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