Membrane Traffic and Muscle: Lessons from Human Disease

Overview

Journal Traffic

Publisher Wiley

Specialties Biology
Physiology

Date 2008 Feb 13

PMID 18266915

Citations 27

Authors

James J Dowling

Elizabeth M Gibbs

Eva L Feldman

Affiliations

Soon will be listed here.

Abstract

Like all mammalian tissues, skeletal muscle is dependent on membrane traffic for proper development and homeostasis. This fact is underscored by the observation that several human diseases of the skeletal muscle are caused by mutations in gene products of the membrane trafficking machinery. An examination of these diseases and the proteins that underlie them is instructive both in terms of determining disease pathogenesis and of understanding the normal aspects of muscle biology regulated by membrane traffic. This review highlights our current understanding of the trafficking genes responsible for human myopathies.

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