Phosphatidylinositol Membrane Anchors and T-cell Activation

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 1991 Jan 1

PMID 1826601

Citations 46

Authors

P J Robinson

Affiliations

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Abstract

A number of lymphocyte proteins are attached to the cell membrane via glycophosphatidylinositol-anchoring domains. Antibodies specific for several of these proteins are potent mitogens for T cells. In this article, Peter Robinson reviews recent evidence for the involvement of these membrane anchors in cell signalling events and discusses their possible significance in providing antigen-independent costimulatory signals to lymphoid cells.

Citing Articles

(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins II: Intercellular Transfer of Matter (Inheritance?) That Matters.

Muller G, Muller T Biomolecules. 2023; 13(6).

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Regulation of PrP(C) signaling and processing by dimerization.

Roucou X Front Cell Dev Biol. 2014; 2:57.

PMID: 25364762 PMC: 4207009. DOI: 10.3389/fcell.2014.00057.

The biological activity of structurally defined inositol glycans.

Goel M, Azev V, dAlarcao M Future Med Chem. 2010; 1(1):95-118.

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Stem cell antigen 2: a new gene involved in the self-renewal of erythroid progenitors.

Bresson-Mazet C, Gandrillon O, Gonin-Giraud S Cell Prolif. 2008; 41(5):726-38.

PMID: 18823497 PMC: 6760816. DOI: 10.1111/j.1365-2184.2008.00554.x.

Signaling through sphingolipid microdomains of the plasma membrane: the concept of signaling platform.

Hoessli D, Ilangumaran S, Soltermann A, Robinson P, Borisch B, Nasir-Ud-Din Glycoconj J. 2001; 17(3 -4):191-7.

PMID: 11201790 DOI: 10.1023/a:1026585006064.