Provisional Hypotheses for the Molecular Genetics of Cognitive Development: Imaging Genetic Pathways in the Anterior Cingulate Cortex

Overview

Journal Biol Psychol

Specialty Psychiatry

Date 2008 Feb 12

PMID 18261834

Citations 4

Authors

John Fossella

Jin Fan

Xun Liu

Kevin Guise

Karin Brocki

Patrick R Hof

Raja Kittappa

Ronald McKay

Michael Posner

Affiliations

Soon will be listed here.

Abstract

Brain imaging genetic research involves a multitude of methods and spans many traditional levels of analysis. Given the vast permutations among several million common genetic variants with thousands of brain tissue voxels and a wide array of cognitive tasks that activate specific brain systems, we are prompted to develop specific hypotheses that synthesize converging evidence and state clear predictions about the anatomical sources, magnitude and direction (increases vs. decreases) of allele- and task-specific brain activity associations. To begin to develop a framework for shaping our imaging genetic hypotheses, we focus on previous results and the wider imaging genetic literature. Particular emphasis is placed on converging evidence that links system-level and biochemical studies with models of synaptic function. In shaping our own imaging genetic hypotheses on the development of Attention Networks, we review relevant literature on core models of synaptic physiology and development in the anterior cingulate cortex.

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