» Articles » PMID: 18258980

Clinical Application of the 70-gene Profile: the MINDACT Trial

Overview
Journal J Clin Oncol
Specialty Oncology
Date 2008 Feb 9
PMID 18258980
Citations 158
Authors
Affiliations
Soon will be listed here.
Abstract

The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.

Citing Articles

Multiomics insights on the onset, progression, and metastatic evolution of breast cancer.

Alvarez-Frutos L, Barriuso D, Duran M, Infante M, Kroemer G, Palacios-Ramirez R Front Oncol. 2024; 13:1292046.

PMID: 38169859 PMC: 10758476. DOI: 10.3389/fonc.2023.1292046.


Prognostic value of tumor necrosis based on the evaluation of frequency in invasive breast cancer.

Chen J, Li Z, Han Z, Kang D, Ma J, Yi Y BMC Cancer. 2023; 23(1):530.

PMID: 37296414 PMC: 10257329. DOI: 10.1186/s12885-023-10943-x.


Clinical Utility of Genomic Assay in Node-Positive Early-Stage Breast Cancer.

Pauls M, Chia S Curr Oncol. 2022; 29(7):5139-5149.

PMID: 35877267 PMC: 9325032. DOI: 10.3390/curroncol29070407.


Definition of High-Risk Early Hormone-Positive HER2-Negative Breast Cancer: A Consensus Review.

Garutti M, Griguolo G, Botticelli A, Buzzatti G, De Angelis C, Gerratana L Cancers (Basel). 2022; 14(8).

PMID: 35454806 PMC: 9029479. DOI: 10.3390/cancers14081898.


Prediction of Breast Cancer Recurrence Using a Deep Convolutional Neural Network Without Region-of-Interest Labeling.

Phan N, Hsu C, Huang C, Tseng L, Chuang E Front Oncol. 2021; 11:734015.

PMID: 34745954 PMC: 8567097. DOI: 10.3389/fonc.2021.734015.