Assessment of Atrial Electromechanical Coupling and Influential Factors in Nonrheumatic Paroxysmal Atrial Fibrillation

Overview

Journal Clin Cardiol

Specialty Cardiology & Vascular Diseases

Date 2008 Feb 8

PMID 18257022

Citations 42

Authors

Qi-Qiong Cui

Wei Zhang

Hu Wang

Xin Sun

Rong Wang

Huan-Yi Yang

Xian-Qiang Meng

Yun Zhang

Hao Wang

Affiliations

Soon will be listed here.

Abstract

Background: Sequential analysis of atrial electromechanical coupling (P-A) by Doppler tissue imaging (DTI) might provide important insight into the mechanisms of paroxysmal atrial fibrillation (PAF).

Hypothesis: The purpose of this study was to evaluate P-A and the dispersion of P-A, and to analyze the influential factors of P-A.

Methods: One hundred and ten patients with PAF and 87 normal controls were enrolled. Using DTI, the time intervals from the beginning of P-wave to the onset of atrioventricular ring motion related to atrial contraction were measured.

Results: Atrial electromechanical coupling at the interventricular septum atrioventricular annulus (P-A1), left lateral mitral annulus (P-A2) and right lateral tricuspid annulus (P-A3) in PAF group were significantly longer than those in control (p < 0.001). The difference between P-A2 and P-A1 (T1), P-A2 and P-A3 (T3) in PAF group were greater than those in control before age correction (p < 0.05). The linear regression analysis showed that the duration of PAF episodes and age were the greatest influential factors of P-A1 (r = 0.564). Left atrial anterior-posterior dimension (LAD) and age were the greatest influential factors of P-A2 (r = 0.459). The LAD was the greatest influential factors of T1 and T3 (r = 0.408, 0.542).

Conclusions: The atrial electromechanical coupling was significantly longer and the dispersion of P-A at left lateral mitral annulus was greater in PAF patients. The prolongation of P-A may be related to left atrial enlargement, long episodes of PAF and aging and the dispersion of P-A at left lateral mitral annulus to LAD.

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