Diabetes and Nephrolithiasis

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2008 Feb 8

PMID 18255008

Citations 21

Authors

Michel Daudon

Paul Jungers

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes is associated with an increased risk of nephrolithiasis, specifically in the form of uric acid (UA) nephrolithiasis. Diabetic patients who produce uric stones exhibit a low urine pH, the key factor of UA crystallization. Production of such acidic urine appears to result from the insulin-resistant state characteristic of diabetes mellitus. Insulin resistance is also involved in the pathogenesis of primary UA nephrolithiasis observed in overweight subjects with the metabolic syndrome. Therefore, UA nephrolithiasis should be considered a possible manifestation of insulin resistance, as it already is for hyperuricemia. Occurrence of UA stones in a patient, especially if overweight or hypertensive, should prompt a search for components of the metabolic syndrome in order to implement therapeutic intervention aimed at preventing the development of type 2 diabetes and atherosclerotic complications. Reciprocally, diabetologists should be aware of the risk of UA stones in their patients.

Citing Articles

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and kidney stones: a cross-sectional study.

Hong H, He Y, Gong Z, Feng J, Qu Y Lipids Health Dis. 2024; 23(1):102.

PMID: 38615008 PMC: 11015599. DOI: 10.1186/s12944-024-02089-x.

Proposal for pathogenesis-based treatment options to reduce calcium oxalate stone recurrence.

Khan S, Canales B Asian J Urol. 2023; 10(3):246-257.

PMID: 37538166 PMC: 10394280. DOI: 10.1016/j.ajur.2023.01.008.

Association of serum bicarbonate with the development of kidney stones in patients with chronic kidney disease: a retrospective cohort study.

Tangri N, Mathur V, Reaven N, Funk S, Whitlock R, Wesson D Clin Kidney J. 2023; 16(7):1113-1121.

PMID: 37398692 PMC: 10310507. DOI: 10.1093/ckj/sfad034.

Metabolic changes in kidney stone disease.

Xu Z, Yao X, Duan C, Liu H, Xu H Front Immunol. 2023; 14:1142207.

PMID: 37228601 PMC: 10203412. DOI: 10.3389/fimmu.2023.1142207.

Unravelling the Complex Relationship between Diet and Nephrolithiasis: The Role of Nutrigenomics and Nutrigenetics.

DAmbrosio V, Ferraro P, Lombardi G, Friso S, Gambaro G Nutrients. 2022; 14(23).

PMID: 36500991 PMC: 9739708. DOI: 10.3390/nu14234961.

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