The Role of Serine/threonine Protein Phosphatase Type 5 (PP5) in the Regulation of Stress-induced Signaling Networks and Cancer

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2008 Feb 7

PMID 18253812

Citations 46

Authors

Teresa Golden

Mark Swingle

Richard E Honkanen

Affiliations

Soon will be listed here.

Abstract

Although the aberrant actions of protein kinases have long been known to contribute to tumor promotion and carcinogenesis, roles for protein phosphatases in the development of human cancer have only emerged in the last decade. In this review, we discuss the data obtained from studies examining the biological and pathological roles of a serine/threonine protein phosphatase, PP5, which suggest that PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress.

Citing Articles

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SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release.

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