Effect of Vitamin K Supplementation on Bone Loss in Elderly Men and Women

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2008 Feb 7

PMID 18252784

Citations 68

Authors

Sarah L Booth

Gerard Dallal

M Kyla Shea

Caren Gundberg

James W Peterson

Bess Dawson-Hughes

Affiliations

Soon will be listed here.

Abstract

Context: Vitamin K has been implicated in bone health, primarily in observational studies. However, little is known about the role of phylloquinone supplementation on prevention of bone loss in men and women.

Objective: The objective of this study was to determine the effect of 3-yr phylloquinone supplementation on change in bone mineral density (BMD) of the femoral neck bone in older men and women who were calcium and vitamin D replete.

Design, Participants, And Intervention: In this 3-yr, double-blind, controlled trial, 452 men and women (60-80 yr) were randomized equally to receive a multivitamin that contained either 500 mug/d or no phylloquinone plus a daily calcium (600 mg elemental calcium) and vitamin D (400 IU) supplement.

Main Outcome Measures: Measurements of the femoral neck, spine (L2-L4), and total-body BMD, bone turnover, and vitamins K and D status were measured every 6-12 months. Intent-to-treat analysis was used to compare change in measures in 401 participants who completed the trial.

Results: There were no differences in changes in BMD measurements at any of the anatomical sites measured between the two groups. The group that received the phylloquinone supplement had significantly higher phylloquinone and significantly lower percent undercarboxylated osteocalcin concentrations compared with the group that did not receive phylloquinone. No other biochemical measures differed between the two groups.

Conclusions: Phylloquinone supplementation in a dose attainable in the diet does not confer any additional benefit for bone health at the spine or hip when taken with recommended amounts of calcium and vitamin D.

Citing Articles

Dietary Menaquinone-9 Supplementation Does Not Influence Bone Tissue Quality or Bone Mineral Density in Mice.

Liu M, Liu C, Cevallos N, Orbach B, Hernandez C, Fu X bioRxiv. 2025; .

PMID: 39975193 PMC: 11838345. DOI: 10.1101/2025.01.29.635567.

Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population.

Xie C, Gong J, Zheng C, Zhang J, Gao J, Tian C Bone Joint Res. 2024; 13(12):750-763.

PMID: 39657786 PMC: 11631259. DOI: 10.1302/2046-3758.1312.BJR-2024-0053.R1.

Vitamin K intake levels are associated with bone health in people aged over 50 years: a NHANES-based survey.

Guo J, Zhou Z, Gong J, Hu W, Liu Y Front Med (Lausanne). 2024; 11:1485095.

PMID: 39655236 PMC: 11625553. DOI: 10.3389/fmed.2024.1485095.

Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies.

Rusu M, Bigman G, Ryan A, Popa D Nutrients. 2024; 16(14.

PMID: 39064799 PMC: 11279569. DOI: 10.3390/nu16142356.

Circulating Osteocalcin Fractions are Associated with Vascular Calcification and Mortality in Chronic Hemodialysis Patients.

Lin R, Hsieh J, Huang C, Yang C, Lin Y, Tarng D Calcif Tissue Int. 2023; 113(4):416-425.

PMID: 37665403 DOI: 10.1007/s00223-023-01122-y.

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