Selective Versus Total Insulin Resistance: a Pathogenic Paradox

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2008 Feb 6

PMID 18249166

Citations 470

Authors

Michael S Brown

Joseph L Goldstein

Affiliations

Soon will be listed here.

Abstract

Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance.

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