» Articles » PMID: 18241780

Mechanisms of Cerebral Injury from Cardiac Surgery

Overview
Journal Crit Care Clin
Specialty Critical Care
Date 2008 Feb 5
PMID 18241780
Citations 25
Authors
Affiliations
Soon will be listed here.
Abstract

Cerebral injury is a frequent complication of cardiac surgery, and it has been associated with high mortality, morbidity, hospital costs; an increased likelihood of admission to a secondary care facility after hospital discharge; and impaired quality of life. This article examines postulated mechanisms for cerebral injury from cardiac surgery. Most emphasis has been placed in the past on the intraoperative interval as being the period of highest cerebral vulnerability. Many clinical cerebral events, however, occur in the postoperative period.

Citing Articles

MRI pattern characterization of cerebral cardioembolic lesions following atrial fibrillation ablation.

Saglietto A, Bertello E, Barra M, Ferraro I, Rovera C, Orzan F Front Cardiovasc Med. 2024; 11:1327567.

PMID: 38327489 PMC: 10847299. DOI: 10.3389/fcvm.2024.1327567.


Association between the intraoperative fluid balance during cardiac surgery and postoperative sequential organ failure assessment score: a post hoc analysis of the BROTHER study, a retrospective multicenter cohort study.

Koga T, Yoshida T, Kotani Y Heart Vessels. 2023; 39(1):57-64.

PMID: 37596414 DOI: 10.1007/s00380-023-02306-0.


Blood Pressure Goals in Critically Ill Patients.

Puttur Rajkumar K, Hicks M, Marchant B, Khanna A Methodist Debakey Cardiovasc J. 2023; 19(4):24-37.

PMID: 37547901 PMC: 10402811. DOI: 10.14797/mdcvj.1260.


Complications of Cardiopulmonary Bypass From an Anesthesia Perspective: A Clinical Review.

Roberts A, Duncan E, Hargrave P, Kingery D, Barnes J, Horstemeyer D HCA Healthc J Med. 2023; 4(1):13-21.

PMID: 37426558 PMC: 10327958. DOI: 10.36518/2689-0216.1525.


Microvascular dysfunction following cardiopulmonary bypass plays a central role in postoperative organ dysfunction.

Kant S, Banerjee D, Sabe S, Sellke F, Feng J Front Med (Lausanne). 2023; 10:1110532.

PMID: 36865056 PMC: 9971232. DOI: 10.3389/fmed.2023.1110532.


References
1.
Barger S, Harmon A . Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature. 1997; 388(6645):878-81. DOI: 10.1038/42257. View

2.
Morgan T, Krumholz H, Lifton R, Spertus J . Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. JAMA. 2007; 297(14):1551-61. DOI: 10.1001/jama.297.14.1551. View

3.
Likosky D, Marrin C, Caplan L, Baribeau Y, Morton J, Weintraub R . Determination of etiologic mechanisms of strokes secondary to coronary artery bypass graft surgery. Stroke. 2003; 34(12):2830-4. DOI: 10.1161/01.STR.0000098650.12386.B3. View

4.
Habib R, Zacharias A, Schwann T, Riordan C, Durham S, Shah A . Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: should current practice be changed?. J Thorac Cardiovasc Surg. 2003; 125(6):1438-50. DOI: 10.1016/s0022-5223(02)73291-1. View

5.
Moody D, Brown W, Challa V, Stump D, Reboussin D, Legault C . Brain microemboli associated with cardiopulmonary bypass: a histologic and magnetic resonance imaging study. Ann Thorac Surg. 1995; 59(5):1304-7. DOI: 10.1016/0003-4975(95)00057-r. View