Prevalence and Determinants of Microalbuminuria Among Diabetic Patients in the United Arab Emirates

Overview

Journal BMC Nephrol

Publisher Biomed Central

Specialty Nephrology

Date 2008 Jan 31

PMID 18230135

Citations 10

Authors

Fatma Al-Maskari

Mohammed El-Sadig

Enyioma Obineche

Affiliations

Soon will be listed here.

Abstract

Background: Microalbuminuria (MA) represents the earliest clinical evidence of diabetic nephropathy and is a predictor of increased cardiovascular morbidity and mortality. The aim of this study was to determine the prevalence of MA among diabetic patients in the Al-Ain district of the United Arab Emirates (UAE).

Methods: The study was part of a general cross-sectional survey carried out to assess the prevalence of diabetes mellitus (DM) complications in Al-Ain district, UAE and was the first to assess the prevalence of MA among diabetic patients. A sample of 513 diabetic patients with a mean age of 53 years (SD: +/- 13) was randomly selected during 2003/2004. All patients completed an interviewer-administered questionnaire and underwent medical assessment. First morning urine collections were obtained and were tested for clinical proteinuria using urine dipsticks and for MA using the single Micral-Test II strips.

Results: MA was found in 61% (95% CI: 56.7-65.7) of the sample and the rate was significantly higher among males, positively related to body mass index (BMI), type 2 DM and presence of other DM complications such as diabetic retinopathy and neuropathy. Of the total sample population, 12.5% (95% CI: 8.1-14.1) had clinical proteinuria.

Conclusion: The prevalence rate of MA was considerably high ( 61%) among diabetic patients in the UAE. Therefore, regular screening for MA is recommended for all diabetic patients, as early treatment is critical for reducing cardiovascular risks and slowing the progression to late stages of diabetic nephropathy (overt proteinuria and end-stage renal disease).

Citing Articles

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References

Molitch M, DeFronzo R, Franz M, Keane W, Mogensen C, Parving H . Nephropathy in diabetes. Diabetes Care. 2003; 27 Suppl 1:S79-83. DOI: 10.2337/diacare.27.2007.s79. View

Goeree R, Manalich J, Grootendorst P, Beecroft M, Churchill D . Cost analysis of dialysis treatments for end-stage renal disease (ESRD). Clin Invest Med. 1995; 18(6):455-64. View

Spooren P, Lekkerkerker J, Vermes I . Micral-Test: a qualitative dipstick test for micro-albuminuria. Diabetes Res Clin Pract. 1992; 18(2):83-7. DOI: 10.1016/0168-8227(92)90003-a. View

Burden A, McNally P, Feehally J, Walls J . Increased incidence of end-stage renal failure secondary to diabetes mellitus in Asian ethnic groups in the United Kingdom. Diabet Med. 1992; 9(7):641-5. DOI: 10.1111/j.1464-5491.1992.tb01860.x. View

Parving H, Lewis J, Ravid M, Remuzzi G, Hunsicker L . Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective. Kidney Int. 2006; 69(11):2057-63. DOI: 10.1038/sj.ki.5000377. View

Gupta D, Verma L, KHOSLA P, Dash S . The prevalence of microalbuminuria in diabetes: a study from north India. Diabetes Res Clin Pract. 1991; 12(2):125-8. DOI: 10.1016/0168-8227(91)90089-v. View

Mogensen C . Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med. 1984; 310(6):356-60. DOI: 10.1056/NEJM198402093100605. View

Wu A, Kong N, de Leon F, Pan C, Tai T, Yeung V . An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: the MicroAlbuminuria Prevalence (MAP) Study. Diabetologia. 2004; 48(1):17-26. DOI: 10.1007/s00125-004-1599-9. View

Liese A, Hense H, Doring A, Stieber J, Keil U . Microalbuminuria, central adiposity and hypertension in the non-diabetic urban population of the MONICA Augsburg survey 1994/95. J Hum Hypertens. 2001; 15(11):799-804. DOI: 10.1038/sj.jhh.1001266. View

10.

Churchill D, Torrance G, Taylor D, BARNES C, Ludwin D, Shimizu A . Measurement of quality of life in end-stage renal disease: the time trade-off approach. Clin Invest Med. 1987; 10(1):14-20. View

11.

Al-Futaisi A, Al-Zakwani I, Almahrezi A, Al-Hajri R, Al-Hashmi L, Al-Muniri A . Prevalence and predictors of microalbuminuria in patients with type 2 diabetes mellitus: a cross-sectional observational study in Oman. Diabetes Res Clin Pract. 2005; 72(2):212-5. DOI: 10.1016/j.diabres.2005.10.001. View

12.

Ahmedani M, Hydrie M, Iqbal A, Gul A, Mirza W, Basit A . Prevalence of microalbuminuria in type 2 diabetic patients in Karachi: Pakistan: a multi-center study. J Pak Med Assoc. 2005; 55(9):382-6. View

13.

Incerti J, Zelmanovitz T, Camargo J, Gross J, de Azevedo M . Evaluation of tests for microalbuminuria screening in patients with diabetes. Nephrol Dial Transplant. 2005; 20(11):2402-7. DOI: 10.1093/ndt/gfi074. View

14.

Verhave J, Hillege H, Burgerhof J, Navis G, de Zeeuw D, de Jong P . Cardiovascular risk factors are differently associated with urinary albumin excretion in men and women. J Am Soc Nephrol. 2003; 14(5):1330-5. DOI: 10.1097/01.asn.0000060573.77611.73. View

15.

. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004; 363(9403):157-63. DOI: 10.1016/S0140-6736(03)15268-3. View

16.

. WHO Expert Committee on Diabetes Mellitus: second report. World Health Organ Tech Rep Ser. 1980; 646:1-80. View

17.

Gerstein H, Mann J, Yi Q, Zinman B, Dinneen S, Hoogwerf B . Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA. 2001; 286(4):421-6. DOI: 10.1001/jama.286.4.421. View

18.

de Jong P, Verhave J, Pinto-Sietsma S, Hillege H . Obesity and target organ damage: the kidney. Int J Obes Relat Metab Disord. 2002; 26 Suppl 4:S21-4. DOI: 10.1038/sj.ijo.0802213. View

19.

Viswanathan M, Snehalatha C, Bhattacharyya P, Mohan V, Ramachandran A . Microalbuminuria in NIDDM patients in south India. Indian J Med Res. 1991; 94:125-9. View

20.

Alzaid A, Sobki S, De Silva V . Prevalence of microalbuminuria in Saudi Arabians with non-insulin-dependent diabetes mellitus: a clinic-based study. Diabetes Res Clin Pract. 1994; 26(2):115-20. DOI: 10.1016/0168-8227(94)90148-1. View