In Vitro Release and Tissue Levels of Ileal Serotonin After Cisplatin-induced Emesis in the Cat

Overview

Journal Clin Auton Res

Date 1991 Dec 1

PMID 1822260

Citations 4

Authors

S Milano

C Simon

L Grelot

Affiliations

Soon will be listed here.

Abstract

We have studied the peripheral mechanisms responsible for the severe vomiting observed in cisplatin treated cats. Release of 5-hydroxytryptamine from isolated portions of the ileum and ileal tissue concentrations of 5-hydroxytryptamine were studied in vitro with control animals and animals previously treated with cisplatin. In the latter, two groups were observed: animals in which cisplatin (single dose, 10 mg/kg) induced vomiting within 4 h and animals that did not vomit within 4 h. Spectrofluorimetric assessment of 5-hydroxytryptamine in the perfusate and ileal tissue revealed that cisplatin increases both release, and tissue levels, of ileal 5-hydroxytryptamine in animals which vomited, whereas only ileal 5-hydroxytryptamine release was increased in animals which did not vomit. This may have clinical implications as cisplatin induced emesis may be more effectively prevented by drugs preventing ileal 5-hydroxytryptamine formation rather than release.

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