Inhibition of Glycolytic Enzymes by 2-phosphotartronate

Overview

Journal Biochem J

Specialty Biochemistry

Date 1976 Mar 1

PMID 182118

Authors

M K Thomas

T G Spring

Affiliations

Soon will be listed here.

Abstract

2-Phosphotartronate has been synthesized by permanganate oxidation of glycerol 2-phosphate and has been tested as an inhibitor of five glycolytic enzymes that bind phosphoglycerate or phosphoglycollate. Competitive inhibition of rabbit muscle phosphoglycerate mutase, enolase and pyruvate kinase was observed. Triose phosphate isomerase and 3-phosphoglycerate kinase were not inhibited.

References

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