Endothelial Progenitor Cells for Cardiovascular Regeneration

Overview

Journal Trends Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2008 Jan 22

PMID 18206807

Citations 43

Authors

Atsuhiko Kawamoto

Douglas W Losordo

Affiliations

Soon will be listed here.

Abstract

Endothelial progenitor cells (EPCs) are peripheral blood mononuclear cells that can differentiate into mature endothelial cells. Adult EPCs were first discovered in human peripheral blood in 1997. Since then, the potency of EPCs for cardiovascular regeneration has been demonstrated in several preclinical studies; and investigators are beginning to evaluate the therapeutic utility of EPCs in early-phase clinical trials. This review summarizes the progression of basic, preclinical, and clinical research into the potential use of EPC therapy for cardiovascular regeneration.

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