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» Articles » PMID: 18202402

Naive Application of Permutation Testing Leads to Inflated Type I Error Rates

Overview
Journal Genetics
Publisher Oxford University Press
Specialty Genetics
Date 2008 Jan 19
PMID 18202402
Citations 41
Authors
G A Churchill
R W Doerge
Affiliations
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Abstract

Failure to account for family structure within populations or in complex mating designs via uninformed applications of permutation testing will lead to inflated type I error rates. Careful consideration of the design factors is essential since some situations allow several valid permutation strategies, and the choice that maximizes statistical power will not always be intuitive.

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