Psychiatric Comorbidity in Young Cocaine Users: Induced Versus Independent Disorders

Overview

Journal Addiction

Specialty Psychiatry

Date 2008 Jan 18

PMID 18199307

Citations 29

Authors

M Jesus Herrero

Antonia Domingo-Salvany

Marta Torrens

M Teresa Brugal

Affiliations

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Abstract

Aims: To examine the psychiatric status of young cocaine users using a validated instrument for the evaluation of psychiatric comorbidity, emphasizing the distinction between independent and induced psychiatric conditions.

Design: Cross-sectional study.

Setting: Barcelona, Spain.

Participants: A cohort of 139 young (18-30 years) adult current regular cocaine users.

Measurements: The Psychiatric Research Interview for Substance and Mental Disorders (PRISM-IV, which produces diagnoses according to DSM-IV criteria, including Axis II antisocial and borderline personality disorders).

Findings: Nearly 42.5% of the subjects presented psychiatric comorbidity. The most common Axis I diagnoses were mood disorders (26.6%) and anxiety disorders (13%). Increasing age, having ever received treatment for drug use and freebase cocaine use were associated with substance-induced disorders diagnoses relative to primary Axis I disorders.

Conclusions: This study has shown a relatively high prevalence of psychiatric comorbidity in cocaine users recruited in non-clinical settings. Future studies examining potential differential factors associated with primary versus substance-induced disorders are necessary to optimize the implementation of more suitable approaching programmes for young regular cocaine users.

Citing Articles

Dysregulation of Plasma Growth Factors and Chemokines in Cocaine Use Disorder: Implications for Dual Diagnosis with Schizophrenia and Antisocial Personality Disorder in an Exploratory Study.

Torres-Galvan S, Flores-Lopez M, Ochoa E, Requena-Ocana N, Araos P, Herrera-Imbroda J Neuropsychobiology. 2024; 83(2):73-88.

PMID: 38768577 PMC: 11210571. DOI: 10.1159/000536265.

Plasma Lysophosphatidic Acid Concentrations in Sex Differences and Psychiatric Comorbidity in Patients with Cocaine Use Disorder.

Requena-Ocana N, Flores-Lopez M, Garcia-Marchena N, Pavon-Moron F, Pedraza C, Wallace A Int J Mol Sci. 2023; 24(21).

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Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits.

Cheng Y, Justice A, Wang Z, Li B, Hancock D, Johnson E BMC Genomics. 2023; 24(1):556.

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Deletion of increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 upregulation of striatal NF-κB expression.

Sayson L, Ortiz D, Lee H, Kim M, Custodio R, Yun J Front Pharmacol. 2023; 14:1135929.

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The Inflammatory Signals Associated with Psychosis: Impact of Comorbid Drug Abuse.

Herrera-Imbroda J, Flores-Lopez M, Ruiz-Sastre P, Gomez-Sanchez-Lafuente C, Bordallo-Aragon A, Rodriguez de Fonseca F Biomedicines. 2023; 11(2).

PMID: 36830990 PMC: 9953424. DOI: 10.3390/biomedicines11020454.